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MYP_163566
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Basic Information
Cyclo(Trp-Tyr), Diketopiperazine (WY)
Anticancer
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antifungal
Cardiovascular ▸ Blood pressure regulation ▸ Antihypertensive
Enzyme modulation ▸ Enzyme inhibition ▸ ACE inhibition ▸ ACE inhibitory
Enzyme modulation ▸ Enzyme inhibition ▸ DPP-IV inhibition ▸ DPP-IV inhibitory
Membrane / Ion-channel modulation ▸ Calcium channel modulation ▸ Calcium channel inhibitor
Metabolic ▸ Glucose metabolism ▸ Antidiabetic
Other / Curated residual function label ▸ Generic enzyme inhibition annotation
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Standard
2 amino acids
C20H21N3O4
Standard
Sequence
WY
Physicochemical Analysis
367.40 Da
5.52
-0.24
-0.45
-0.1205
-1.10
0.40
0.54
5.00
0.00
1.0000
6990.00
6990.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
128.44
1.56
5.0
4.0
7.0
27.0
3.0
1.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0091323 VERIFIED: YES
Provenance & Taxonomy
Comamonas testosteroni [Bacterium]
Structure & Mods
cyclic peptide topology [Cyclic]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal
Fusarium oxysporum ATCC 14838
64 μg/mL
MIC
PMID24120705 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/24120705/
RECORD: Rec_0097741 VERIFIED: YES
Provenance & Taxonomy
Comamonas testosteroni [Bacterium]
Structure & Mods
cyclic peptide topology [Cyclic]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal
Penicillium expansum MTCC 2006
32 μg/mL
MIC
PMID24120705 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/24120705/
RECORD: Rec_0114024 VERIFIED: YES
Provenance & Taxonomy
Comamonas testosteroni [Bacterium]
Structure & Mods
cyclic peptide topology [Cyclic]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal
Human breast adenocarcinoma MCF-7
200 μM
IC50
PMID24120705 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/24120705/
RECORD: Rec_0126707 VERIFIED: YES
Provenance & Taxonomy
Bos taurus [Animal]
9913;0
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antioxidant
PaperHernandez-Ledesma B., Amigo L., Recio I., Bartolome B.. ACE-inhibitory and radicalscavenging activity of peptides derived from b-lactoglobulin f(19-25). Interactions with ascorbic acid. J. Agric. Food Chem., 55 (2007), 3392-3397.
RECORD: Rec_0128410 VERIFIED: YES
Provenance & Taxonomy
Comamonas testosteroni [Bacterium]
Structure & Mods
head-to-tail cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal Anti-Gram-positive
Staphylococcus aureus
32 μg/mL
MIC
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