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MYP_163559
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Basic Information
Defensin-TK
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antifungal
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Standard
41 amino acids
C189H288N50O56S7
Standard
Sequence
SPAIWGCDSFLGYCRLACFAHEASVGQKECAEGMLCCIPNV
Physicochemical Analysis
4381.06 Da
4.83
-2.50
-2.86
-0.0611
0.45
0.40
0.23
46.56
73.90
0.0976
6990.00
7365.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1658.43
-16.00
62.0
62.0
137.0
302.0
8.0
42.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0002000 VERIFIED: YES
Provenance & Taxonomy
Theloderma kwangsiensis [Animal]
Defensin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antifungal
fungus Candida albicans ATCC 2002
6 μg/mL
MIC
PaperA novel defensin-like antimicrobial peptide from the skin secretions of the tree frog, Theloderma kwangsiensis
RECORD: Rec_0012412 VERIFIED: YES
Provenance & Taxonomy
Rhacophorus puerensis [Animal]
Defensin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
-
Escherichia coli TOP10
Mex pooled growth assay (OD_ID at 4.5 h; Wald adjusted p-value)
PaperKoch P, Schmitt S, Cardner M, Beerenwinkel N, Panke S, Held M. Discovery of antimicrobials by massively parallelized growth assays (Mex). Scientific Reports. 2022;12:4097. doi:10.1038/s41598-022-07755-7 PMID35260685 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/35260685/
RECORD: Rec_0092019 VERIFIED: YES
Provenance & Taxonomy
Theloderma kwangsiensis [Animal]
Defensin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antifungal
Staphylococcus aureus ATCC 2592
3 μg/mL
MIC
PaperA novel defensin-like antimicrobial peptide from the skin secretions of the tree frog, Theloderma kwangsiensis
RECORD: Rec_0116952 VERIFIED: YES
Provenance & Taxonomy
Theloderma kwangsiense [Animal]
Defensin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal Hemolytic Anti-Gram-positive
Staphylococcus aureus
3 μM
MIC
RECORD: Rec_0117386 VERIFIED: YES
Provenance & Taxonomy
Theloderma kwangsiense [Animal]
Defensin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal Hemolytic Anti-Gram-negative
Escherichia coli
12 μM
MIC
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