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MYP_163558
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Basic Information
Neurotensin
—
Standard
13 amino acids
C76H122N22O21
Standard
Sequence
QLYENKSRRPYIL
Physicochemical Analysis
1679.92 Da
9.70
1.76
1.55
0.1354
-1.25
0.38
-0.38
110.15
90.00
0.1538
2980.00
2980.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
737.72
-5.59
26.0
23.0
55.0
119.0
3.0
14.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0189659 VERIFIED: NO
Provenance & Taxonomy
Cavia porcellus [Animal]
Neurotensin
10141
Structure & Mods
linear peptide [Linear]
noncanonical stereochemical modification [Modified]
Pyroglutamate
Bio-Activity Profile
-
Mammalian: 0.8 hour; Yeast: 10 min; E. coli: >10 hour
PaperSource-linked PubMed record(s) for Neurotensin (Cavia porcellus): PMID 3087775 PMID3087775 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/3087775/
RECORD: Rec_0433514 VERIFIED: YES
Provenance & Taxonomy
Cavia porcellus [Animal]
Neurotensin
Structure & Mods
linear peptide [Linear]
noncanonical stereochemical modification [Modified]
Pyroglutamate
N-terminal pyroglutamate
Bio-Activity Profile
Smooth muscle contracting Neuropeptide
Cavia porcellus ileum longitudinal muscle
~0.3 nM
ED50; longitudinal muscle contraction assay
PaperBinding and biologic activity of neurotensin in guinea pig ileum PMID7700847
RECORD: Rec_0433515 VERIFIED: YES
Provenance & Taxonomy
Cavia porcellus [Animal]
Neurotensin
Structure & Mods
linear peptide [Linear]
noncanonical stereochemical modification [Modified]
Pyroglutamate
N-terminal pyroglutamate
Bio-Activity Profile
Smooth muscle contracting Neuropeptide
Cavia porcellus ileum longitudinal muscle; atropine-resistant component
~1.4 nM
ED50; ileum contraction assay in 1 μM atropine
PaperBinding and biologic activity of neurotensin in guinea pig ileum PMID7700847
RECORD: Rec_0433516 VERIFIED: YES
Provenance & Taxonomy
Cavia porcellus [Animal]
Neurotensin
Structure & Mods
linear peptide [Linear]
noncanonical stereochemical modification [Modified]
Pyroglutamate
N-terminal pyroglutamate
Bio-Activity Profile
Receptor binding Neuropeptide
Neurotensin receptor sites in Cavia porcellus ileum muscle and myenteric plexus
~0.1 nM
Kd; 125I-neurotensin receptor-binding assay
PaperBinding and biologic activity of neurotensin in guinea pig ileum PMID7700847
RECORD: Rec_0433517 VERIFIED: YES
Provenance & Taxonomy
Cavia porcellus [Animal]
Neurotensin
Structure & Mods
linear peptide [Linear]
noncanonical stereochemical modification [Modified]
Pyroglutamate
N-terminal pyroglutamate
Bio-Activity Profile
Receptor binding Neuropeptide
Neurotensin receptor sites in Cavia porcellus ileum muscle and myenteric plexus
~2 nM
Kd; 125I-neurotensin receptor-binding assay
PaperBinding and biologic activity of neurotensin in guinea pig ileum PMID7700847