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MYP_163534
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Basic Information
Brevinin-2SKa
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Standard
33 amino acids
C153H258N42O44S3
Standard
Sequence
GLFSAFKKVGKNVLKNVAGSLMDNLKCKVSGEC
Physicochemical Analysis
3486.14 Da
9.51
3.74
3.50
0.1133
0.10
0.74
0.05
0.74
88.48
0.0606
0.00
125.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1415.20
-14.90
50.0
51.0
124.0
242.0
2.0
35.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0050087 VERIFIED: YES
Provenance & Taxonomy
Rana sakuraii [Animal]
Brevinin
Structure & Mods
Linear peptide with a single intramolecular disulfide-stabilized loop [Linear]
Gene-encoded natural peptide composed of standard L-amino acids [L]
27-33
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-negative
Escherichia coli
3.0 μM
MIC
PaperH. Suzuki et al. / Peptides 28 (2007) 505-514. Expression of genes encoding antimicrobial and bradykinin-related peptides in skin of the stream brown frog Rana sakuraii
RECORD: Rec_0056949 VERIFIED: YES
Provenance & Taxonomy
Rana temporaria [Animal]
Brevinin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
-
Escherichia coli TOP10
Mex pooled growth assay (OD_ID at 4.5 h; Wald adjusted p-value)
PaperKoch P, Schmitt S, Cardner M, Beerenwinkel N, Panke S, Held M. Discovery of antimicrobials by massively parallelized growth assays (Mex). Scientific Reports. 2022;12:4097. doi:10.1038/s41598-022-07755-7 PMID35260685 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/35260685/
RECORD: Rec_0072220 VERIFIED: YES
Provenance & Taxonomy
Rana sakuraii [Animal]
Brevinin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
27-33
Bio-Activity Profile
Antimicrobial
Escherichia coli
3 μM
MIC
PaperExpression of genes encoding antimicrobial and bradykinin-related peptides in skin of the stream brown frog Rana sakuraii.
RECORD: Rec_0091266 VERIFIED: YES
Provenance & Taxonomy
Rana sakuraii [Animal]
Brevinin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
27-33
Bio-Activity Profile
Antimicrobial
Staphylococcus aureus
50 μM
MIC
PaperExpression of genes encoding antimicrobial and bradykinin-related peptides in skin of the stream brown frog Rana sakuraii.
RECORD: Rec_0251193 VERIFIED: NO
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide; DSSP H 72.7%, E 0.0%, T 12.1%, C 15.2% [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antibacterial Antimicrobial Anti-Gram-positive Anti-Gram-negative
PaperCAMP: Collection of sequences and structures of antimicrobial peptides PMID24265220 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/24265220/
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