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MYP_163507
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Basic Information
ATN-161
Antimicrobial
Antiviral
Antiviral ▸ Anti-Coronavirus ▸ Anti-SARS-CoV-2
Antiviral ▸ Antiviral mechanism ▸ Viral replication inhibition
Membrane / Ion-channel modulation ▸ Sodium channel modulation ▸ Sodium channel inhibitor
Standard
5 amino acids
C21H32N8O8S
Standard
Sequence
PHSCN
Physicochemical Analysis
556.59 Da
7.12
0.04
-0.09
0.0072
-1.32
0.22
-0.19
73.20
0.00
0.0000
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
257.73
-4.47
10.0
10.0
15.0
38.0
2.0
5.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0104534 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Acylation
Amidation
Bio-Activity Profile
Antimicrobial Anti-SARS-CoV-2
Virus:SARS-CoV-2:inhibition of replication In VeroE6 cells
3.16 μM
IC50
PMID33102950 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/33102950/
RECORD: Rec_0245347 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Protein-derived synthetic peptide
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Acylation
Amidation
Acylation
Bio-Activity Profile
Antiviral Anti-SARS-CoV-2 Replication inhibition
SARS-CoV-2 | VeroE6 cells
3.16 μM
IC50
Mammalian: >20 h; Yeast: >20 h; E. coli: ?
PaperThe Integrin Binding Peptide, ATN-161, as a Novel Therapy for SARS-CoV-2 Infection. | Beddingfield BJ, Iwanaga N, Chapagain PP, Zheng W, Roy CJ, Hu TY, Kolls JK, Bix GJ. | JACC Basic Transl Sci. 2021 Jan;6(1):1-8. | DOI:10.1016/j.jacbts.2020.10.003 | PMID:33102950 PMID33102950 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/33102950/
RECORD: Rec_0274755 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antiviral
SARS-CoV-2
PMID33102950 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/33102950/