Peptide Database

Peptide NameBactericidal permeability-increasing protein (BPI)

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibiotic activity

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Venom / Toxin ▸ General toxin ▸ Cytotoxin

Standard StatusStandard

Sequence Length486 amino acids

Chemical FormulaC2399H3696N626O715S18

DescriptionStandard

        MLQPVILLFVLGTCSAVENPGIEITVNNKGLQYGKHAGADWIQGILGNITLPFMDGRIRVGCFSSLYYTFTDTRIRKCDLPEPSVEFSPEAAGLNMSISGLSVALTGEWMASFSFLQSVGSFNMALFSVDVTSVVKLDRDNNGHLSVSSVSCEAHVENVDISLSGGASWVFQALMNRHKSQFKQNIEDGICPQVEKSIANLEHYLQVMNVSFDVDHTLAVNLSLTASPDINPSSLNVGLKGEFFSIQTHNDPPFEAQPFTVPVQGDYMFSVVLSEYTVNSALYGYYSAGLFNIFINDSMIPPDFPVHLNTSSMGPYIPQLPKALLGLQMNLQVNATSVPMVTFQPDWAKQSFHATAEAFAVQPNGTQTPLFQLRADSAFSGQSWIDAGKVKGNVSVDNFTLTLISSDVGPVNTKTLAKSTREGIEMILTRVNEALSRGLDLPRLKRAKFVNSVLKVEQGFVSFFSDAEVWPTDRGFNRPKHTHEFF
    

Molecular Weight53323.94 Da

Isoelectric Point (pI)5.30

Net Charge (pH 7.0)-12.53

Net Charge (pH 7.4) -13.47

Charge Density (pH 7.0) -0.0258

GRAVY Index0.01

Hydrophobic Moment 0.74

Boman Index0.13

Instability Index38.03

Aliphatic Index 87.20

Aromaticity 0.1008

Extinction Coeff. Reduced 47900.00

Extinction Coeff. Oxidized 48150.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0379722 VERIFIED: NO

Provenance & Taxonomy

OrganismCynoglossus semilaevis [Bacterium]

FamilyBPI

Tax ID244447

Structure & Mods

Configlinear polypeptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Anti-Gram-negative Cytotoxin Non-hemolytic

TargetGram-negative bacteria

MethodQualitative functional evidence