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MYP_163491
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Basic Information
Defensin-like protein (Sesquin; Plant defensin)
Anticancer
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antibacterial ▸ Anti-Mycobacterium
Antimicrobial ▸ Antifungal
Antiviral
Antiviral ▸ Anti-HIV
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Standard
10 amino acids
C48H76N12O19S
Standard
Sequence
KTCENLADTY
Physicochemical Analysis
1157.25 Da
4.37
-1.25
-1.47
-0.1248
-0.90
0.50
-0.18
-14.52
49.00
0.1000
1490.00
1490.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
529.62
-6.19
19.0
19.0
37.0
80.0
1.0
10.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0315160 VERIFIED: YES
Provenance & Taxonomy
Vigna unguiculata subsp.sesquipedalis [Plant]
Defensin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal Anticancer Antiviral Anti-HIV Cytotoxic Anti-Gram-positive
Bacillus subtilis
98±2 μM
IC50
PMID15949629 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/15949629/
RECORD: Rec_0317284 VERIFIED: YES
Provenance & Taxonomy
Vigna unguiculata subsp. sesquipedalis [Plant]
Defensin
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
disulfide bond; sites not specified
Bio-Activity Profile
Antimicrobial Antiviral Antifungal Anti-HIV Anti-Gram-negative Anti-Gram-positive Anticancer Non-hemolytic
Staphylococcus aureus
PMID15949629 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/15949629/
RECORD: Rec_0319982 VERIFIED: NO
Provenance & Taxonomy
Chinese long [Plant]; Insecta [Animal]
33090; 50557
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Anticancer
PaperAPD2: the updated antimicrobial peptide database and its application in peptide design PMID18957441 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/18957441/
RECORD: Rec_0329331 VERIFIED: YES
Provenance & Taxonomy
Vigna unguiculata subsp. sesquipedalis [Plant]
Defensin
Structure & Mods
Single-chain peptide backbone represented as a linear sequence entry [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal Antiviral Anti-Gram-positive Anti-Gram-negative
Mycosphaerella arachidicola
0.15 μM
IC50
PMID15949629 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/15949629/
RECORD: Rec_0329830 VERIFIED: NO
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal Anticancer Antiviral Anti-Gram-positive Anti-Gram-negative
PaperCAMP: Collection of sequences and structures of antimicrobial peptides PMID24265220 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/24265220/
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