Peptide Database

Peptide NameDefensin-like protein (Sesquin; Plant defensin)

Function Ontology

Anticancer

Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic

Antimicrobial

Antimicrobial ▸ Antibacterial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive

Antimicrobial ▸ Antibacterial ▸ Anti-Mycobacterium

Antimicrobial ▸ Antifungal

Antiviral

Antiviral ▸ Anti-HIV

Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Venom / Toxin ▸ General toxin ▸ Cytotoxic

Standard StatusStandard

Sequence Length10 amino acids

Chemical FormulaC48H76N12O19S

DescriptionStandard

        KTCENLADTY
    

Molecular Weight1157.25 Da

Isoelectric Point (pI)4.37

Net Charge (pH 7.0)-1.25

Net Charge (pH 7.4) -1.47

Charge Density (pH 7.0) -0.1248

GRAVY Index-0.90

Hydrophobic Moment 0.50

Boman Index-0.18

Instability Index-14.52

Aliphatic Index 49.00

Aromaticity 0.1000

Extinction Coeff. Reduced 1490.00

Extinction Coeff. Oxidized 1490.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 529.62

LogP -6.19

H-bond Donors 19.0

H-bond Acceptors 19.0

Rotatable Bonds 37.0

Heavy Atoms 80.0

Ring Count 1.0

Amide Bonds 10.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0033633 VERIFIED: YES

Provenance & Taxonomy

OrganismVigna unguiculata subsp. sesquipedalis [Animal]

FamilyDefensin

Structure & Mods

Configtopology not specified [Not included yet]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antiviral Antifungal

TargetBotrytis cinerea

Activity2.5±0.01 μM

MethodIC50

RECORD: Rec_0040182 VERIFIED: YES

Provenance & Taxonomy

OrganismVigna unguiculata subsp.sesquipedalis [Plant]

FamilyDefensin

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antimicrobial Antibacterial Antifungal Anticancer Antiviral Anti-HIV Cytotoxic

TargetMycosphaerella arachidicola

Activity0.15±0.002 μM

MethodIC50

RECORD: Rec_0048430 VERIFIED: YES

Provenance & Taxonomy

OrganismVigna unguiculata subsp.sesquipedalis [Plant]

FamilyDefensin

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antimicrobial Antibacterial Antifungal Anticancer Antiviral Anti-HIV Cytotoxic Anti-Gram-positive

TargetBacillus megaterium

RECORD: Rec_0056305 VERIFIED: YES

Provenance & Taxonomy

OrganismVigna unguiculata subsp. sesquipedalis [Plant]

FamilyDefensin

Structure & Mods

Configdisulfide-constrained cyclic peptide [Cyclic]

Chiralitycanonical L-amino-acid peptide [L]

Disulfidedisulfide bond; sites not specified

Bio-Activity Profile

Function

Antimicrobial Antiviral Antifungal Anti-HIV Anti-Gram-negative Anti-Gram-positive Anticancer Non-hemolytic

TargetEscherichia coli

RECORD: Rec_0058380 VERIFIED: NO

Provenance & Taxonomy

Organismnot reported [other]

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antimicrobial

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