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MYP_163491
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Basic Information
Defensin-like protein (Sesquin; Plant defensin)
Anticancer
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antibacterial ▸ Anti-Mycobacterium
Antimicrobial ▸ Antifungal
Antiviral
Antiviral ▸ Anti-HIV
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Standard
10 amino acids
C48H76N12O19S
Standard
Sequence
KTCENLADTY
Physicochemical Analysis
1157.25 Da
4.37
-1.25
-1.47
-0.1248
-0.90
0.50
-0.18
-14.52
49.00
0.1000
1490.00
1490.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
529.62
-6.19
19.0
19.0
37.0
80.0
1.0
10.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0385617 VERIFIED: YES
Provenance & Taxonomy
Vigna unguiculata subsp.sesquipedalis [Plant]
Defensin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal Anticancer Antiviral Anti-HIV Cytotoxic Anti-Gram-positive
Bacillus megaterium
105±5 μM
IC50
PMID15949629 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/15949629/
RECORD: Rec_0400601 VERIFIED: YES
Provenance & Taxonomy
Vigna unguiculata subsp. sesquipedalis [Animal]
Defensin
Structure & Mods
topology not specified [Not included yet]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antiviral Antifungal
Proteus vulgaris
PaperPubMed PMID: 15949629 PMID15949629 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/15949629/
RECORD: Rec_0406138 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
-
Escherichia coli TOP10
Mex pooled growth assay (OD_ID at 4.5 h; Wald adjusted p-value)
PaperKoch P, Schmitt S, Cardner M, Beerenwinkel N, Panke S, Held M. Discovery of antimicrobials by massively parallelized growth assays (Mex). Scientific Reports. 2022;12:4097. doi:10.1038/s41598-022-07755-7 PMID35260685 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/35260685/
RECORD: Rec_0417688 VERIFIED: YES
Provenance & Taxonomy
Vigna unguiculata subsp. sesquipedalis [Animal]
Defensin
Structure & Mods
topology not specified [Not included yet]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antiviral Antifungal
Escherichia coli
PaperPubMed PMID: 15949629 PMID15949629 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/15949629/
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