Peptide Database

Peptide NameBactericidal permeability-increasing protein (BPI)

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibiotic activity

Venom / Toxin ▸ General toxin ▸ Cytotoxin

Standard StatusStandard

Sequence Length485 amino acids

Chemical FormulaC2386H3757N611O698S16

DescriptionStandard

        MLSLLILLLNLTNHAFGQNPAIKAILTNKGLQYGSHIGADWMQEKIGSVIIPDVRGGVDIGIGTVHYVLDGISVSGCDVPEPSVEFYEGVGLKAVISGLSISMSGNWHTRFGIITDGGSFDLAVFNVDVTSVVQIGSDPSGHISISSKNCDAKVGEASINFHGGASLIFQPFVSLFHHRIKAIIEERICPLVEEHVTDLERHLAEMQVSFKVNSALVLDVPLTNSPLVDSISLGLDLKGEFYSVQSHTDPPFKAEPFHLAEDKGHMLSLGLSEFTVNSASYAYFSAGLLQAQINDSMIPKTSPFRLNTTSFGPLIPQLPKLFPNMLMELQVYARDLPMFSFQADKLTMEFPGAVKAFAIQPNASRTPLFKLNVDSIFSGTIRISEEKLKGLVELSNFTLTLASSEVGTFQTAALEKFMKLGMKISVLAKLNAKLEEGIVLPTMHHIHLVNPALKIQQGFVSIASDLDVKSGEGESLSEGIYHYRL
    

Molecular Weight52683.07 Da

Isoelectric Point (pI)5.63

Net Charge (pH 7.0)-12.98

Net Charge (pH 7.4) -14.21

Charge Density (pH 7.0) -0.0268

GRAVY Index0.18

Hydrophobic Moment 0.68

Boman Index0.19

Instability Index31.45

Aliphatic Index 103.51

Aromaticity 0.0804

Extinction Coeff. Reduced 24410.00

Extinction Coeff. Oxidized 24535.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

3D PDB MODEL

Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber in the current view mode. Use the buttons to zoom.

2D CHEMICAL STRUCTURE

Drag to move

Drag to move. Use the buttons to zoom.

RECORD: Rec_0214227 VERIFIED: NO

Provenance & Taxonomy

OrganismOncorhynchus kisutch [Animal]

FamilyBPI

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Anti-Gram-negative Cytotoxin

TargetGram-negative bacteria

MethodQualitative functional evidence