Peptide Database

Peptide NameBactericidal permeability-increasing protein (BPI)

Function Ontology

Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Venom / Toxin ▸ General toxin ▸ Cytotoxic

Standard StatusStandard

Sequence Length503 amino acids

Chemical FormulaC2467H3957N703O690S23

DescriptionStandard

        MARGPDNTPSWAPLVVLVAVGTGMAGAPNPGAVARISQKGLDYACQQGMAALQKELEKIRIPDFSGKFKIKHLGNGHYSFYSMQMRGFQLPNSQIRMVPSVGLGLSSRNASVRISGRWKARKNFLKTSGGFDLSVEGVSISADLKLGRDPTSGHATVTCSNCSSHIDRVHVRISGRLGWLIRLFRKKIESSLRNNMNSQICNTMTRAVSSKLQPFIQTLPVTAKLDAVAEVNYSLVAPPTVTAETLDVELKGEVSRRDHHSPPPFAPPALALPAVHDRMVYLGLSEYLFNTAGLVYQQAGALSLVLKDDMIPKDSPFRLTTKFLGTLLPQVAKMFPNMEAQFHISVSSPPHLSMQPAGLAFRPTLETQAFAVLPNSSLASLFLLGMSTNASMKVSARSERIVGELRLDRLLLELKHTNVGNFPVELLQALMDYVVPTLVLPRVNQRLQKGFPLPMPARVQLYNLELQSHQNFLMFGADVRYARSRRGGGAVRSCPFRFLRGPF
    

Molecular Weight55242.60 Da

Isoelectric Point (pI)10.15

Net Charge (pH 7.0)25.53

Net Charge (pH 7.4) 24.55

Charge Density (pH 7.0) 0.0508

GRAVY Index-0.06

Hydrophobic Moment 0.71

Boman Index0.05

Instability Index44.02

Aliphatic Index 91.11

Aromaticity 0.0736

Extinction Coeff. Reduced 31400.00

Extinction Coeff. Oxidized 31650.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0310856 VERIFIED: NO

Provenance & Taxonomy

OrganismCarlito syrichta [Animal]

FamilyBPI/LBP

Tax ID1868482

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antimicrobial Anti-Gram-negative Cytotoxic Non-hemolytic

TargetGram-negative bacteria