Peptide Database

Peptide NameSLAY-screened peptide P5377

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Standard StatusStandard

Sequence Length18 amino acids

Chemical FormulaC101H134N28O23S2

DescriptionStandard

        ARPNTSPFMFHGWPCWHT
    

Molecular Weight2172.45 Da

Isoelectric Point (pI)8.31

Net Charge (pH 7.0)0.96

Net Charge (pH 7.4) 0.66

Charge Density (pH 7.0) 0.0534

GRAVY Index-0.66

Hydrophobic Moment 0.19

Boman Index0.11

Instability Index69.57

Aliphatic Index 5.56

Aromaticity 0.2222

Extinction Coeff. Reduced 11000.00

Extinction Coeff. Oxidized 11000.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 786.27

LogP -5.75

H-bond Donors 28.0

H-bond Acceptors 28.0

Rotatable Bonds 57.0

Heavy Atoms 154.0

Ring Count 11.0

Amide Bonds 18.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0229782 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Familyp53-derived

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitystereochemistry not specified [Other]

Bio-Activity Profile

Function

Antimicrobial Antibacterial

Targetrecombinant Escherichia coli surface-display screening

MethodSLAY screening

PaperAshley T Tucker, Sean P Leonard, Cory D DuBois, Gregory A Knauf, Ashley L Cunningham, Claus O Wilke, M Stephen Trent, Bryan W Davies. Discovery of Next-Generation Antimicrobials through Bacterial Self-Screening of Surface-Displayed Peptide Libraries. Cell. 2018 Jan 25;172(3):618-628.e13. doi: 10.1016/j.cell.2017.12.009. Epub 2018 Jan 4. PMID29307492 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29307492/