Peptide Database

Peptide NameBactericidal permeability-increasing protein

Function Ontology

Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibiotic activity

Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Venom / Toxin ▸ General toxin ▸ Cytotoxic

Standard StatusStandard

Sequence Length114 amino acids

Chemical FormulaC553H886N148O167S3

DescriptionStandard

        PDLSGYEKFGLGNVKYNISRIRVTAVEFPSASISLIPGTGIKLVIGNASLTIDMNWNIRTWMFKNSGRSTVYISKVFVTAIFSTPLDNTGHTSISLTSCRTTSGDIDIKLNGKS
    

Molecular Weight12376.04 Da

Isoelectric Point (pI)9.67

Net Charge (pH 7.0)5.04

Net Charge (pH 7.4) 4.89

Charge Density (pH 7.0) 0.0442

GRAVY Index0.03

Hydrophobic Moment 0.53

Boman Index0.11

Instability Index12.63

Aliphatic Index 93.16

Aromaticity 0.0877

Extinction Coeff. Reduced 15470.00

Extinction Coeff. Oxidized 15470.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 5075.88

LogP -57.23

H-bond Donors 183.0

H-bond Acceptors 176.0

Rotatable Bonds 409.0

Heavy Atoms 871.0

Ring Count 17.0

Amide Bonds 121.0

3D PDB MODEL

Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber in the current view mode. Use the buttons to zoom.

2D CHEMICAL STRUCTURE

Drag to move

Drag to move. Use the buttons to zoom.

RECORD: Rec_0038576 VERIFIED: NO

Provenance & Taxonomy

OrganismEudyptes filholi [Animal]

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Anti-Gram-negative Cytotoxic Non-hemolytic Non-ribosomal

TargetGram-negative bacteria

MethodQualitative functional evidence

RECORD: Rec_0295108 VERIFIED: NO

Provenance & Taxonomy

OrganismEudyptes chrysocome [Animal]

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Anti-Gram-negative Cytotoxic Non-hemolytic Non-ribosomal

TargetGram-negative bacteria

MethodQualitative functional evidence

RECORD: Rec_0347180 VERIFIED: NO

Provenance & Taxonomy

OrganismEudyptes sclateri [Animal]

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Anti-Gram-negative Cytotoxic Non-hemolytic Non-ribosomal

TargetGram-negative bacteria

MethodQualitative functional evidence