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MYP_163311
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Basic Information
Kn2-7 (BmKn2 peptide derivative)
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antifungal
Antiviral
Antiviral ▸ Anti-HIV ▸ Anti-HIV-1
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Venom / Toxin ▸ General toxin ▸ Toxic
Wound healing/Regeneration ▸ Wound healing
Standard
13 amino acids
C81H140N24O14
Standard
Sequence
FIKRIARLLRKIF
Physicochemical Analysis
1674.13 Da
12.00
4.76
4.55
0.3660
0.55
1.10
-0.10
36.06
157.69
0.1538
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
650.26
-1.00
25.0
19.0
59.0
119.0
2.0
12.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0206507 VERIFIED: YES
Provenance & Taxonomy
Synthetic construct [Synthetic]
32630
Structure & Mods
topology not specified [Not included yet]
stereochemistry not specified [Other]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Pseudomonas aeruginosa A093115
100 μg/mL
MIC
PMID22792229 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22792229/
RECORD: Rec_0210095 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Penicillin-resistant Staphylococcus epidermidis
6.25 μg/mL
MIC
PMID22792229 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22792229/
RECORD: Rec_0210249 VERIFIED: YES
Provenance & Taxonomy
Synthetic construct [Synthetic]
32630
Structure & Mods
topology not specified [Not included yet]
stereochemistry not specified [Other]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Escherichia coli ATCC 25922
25 μg/mL
MIC
PMID22792229 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22792229/
RECORD: Rec_0222013 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Kn2-7
32630
Structure & Mods
linear peptide [Linear]
all-D amino-acid peptide [D]
Amidation
D-Phe at 1st, and 13th position, D-Ile at 2nd, 5th, and 12th position, D-Lys at 3rd, and 11th position, D-Arg at 4th, 7th, and 10th position, D-Ala at 6th position, D-Leu at 8th, and 9th position
Bio-Activity Profile
Antimicrobial Antibacterial
Human plasma: Remains 78.5% of dKn2-7, at 37°C
PaperChen W, Kirui D, Millenbaugh NJ. Optimized peptide extraction method for analysis of antimicrobial peptide Kn2-7/dKn2-7 stability in human serum by LC-MS. Future Sci OA. Future Sci OA. 2022 Jul 20;8(6):FSO807. PMID:35909998 https://pubmed.ncbi.nlm.nih.gov/35909998/ PMID35909998 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/35909998/
RECORD: Rec_0235820 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Bacillus subtilis AB91021
6.25 μg/mL
MIC
PMID22792229 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22792229/
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