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MYP_163311
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Basic Information
Kn2-7 (BmKn2 peptide derivative)
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antifungal
Antiviral
Antiviral ▸ Anti-HIV ▸ Anti-HIV-1
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Venom / Toxin ▸ General toxin ▸ Toxic
Wound healing/Regeneration ▸ Wound healing
Standard
13 amino acids
C81H140N24O14
Standard
Sequence
FIKRIARLLRKIF
Physicochemical Analysis
1674.13 Da
12.00
4.76
4.55
0.3660
0.55
1.10
-0.10
36.06
157.69
0.1538
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
650.26
-1.00
25.0
19.0
59.0
119.0
2.0
12.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0128691 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antiviral Wound healing
Staphylococcus aureus AB94004 or ATCC 25923 or MRSA
3.13 μg/mL
MIC
PaperAntibacterial activity and mechanism of a scorpion venom peptide derivative in vitro and in vivo.
RECORD: Rec_0132655 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Protein-derived synthetic peptide
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antiviral Anti-HIV-1
Human immunodeficiency viruss-1 (HIV-1)
1.65 μM
EC50
Mammalian: 1.1 h; Yeast: 3 min; E. coli: 2 min
PaperAnti-HIV-1 activity of a new scorpion venom peptide derivative Kn2-7. | Chen Y, Cao L, Zhong M, Zhang Y, Han C, Li Q, Yang J, Zhou D, Shi W, He B, Liu F, Yu J, Sun Y, Cao Y, Li Y, Li W, Guo D, Cao Z, Yan H. | PLoS One. 2012;7(4):e34947. | DOI:10.1371/journal.pone.0034947 | PMID:22536342 PMID22536342 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22536342/
RECORD: Rec_0135292 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Pseudomonas aeruginosa A092994
50 μg/mL
MIC
PMID22792229 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22792229/
RECORD: Rec_0141220 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antiviral Wound healing
Micrococcus luteus AB93113
6.25 μg/mL
MIC
PaperAntibacterial activity and mechanism of a scorpion venom peptide derivative in vitro and in vivo.
RECORD: Rec_0146396 VERIFIED: YES
Provenance & Taxonomy
Synthetic construct [Synthetic]
32630
Structure & Mods
topology not specified [Not included yet]
stereochemistry not specified [Other]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Escherichia coli AB94012
6.25 μg/mL
MIC
PMID22792229 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22792229/
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