Peptide Database

Peptide NameSLAY-screened peptide P4685

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Standard StatusStandard

Sequence Length20 amino acids

Chemical FormulaC103H149N31O27S2

DescriptionStandard

        AHSSFINHCHFCIAYPVNTR
    

Molecular Weight2317.61 Da

Isoelectric Point (pI)8.12

Net Charge (pH 7.0)1.04

Net Charge (pH 7.4) 0.67

Charge Density (pH 7.0) 0.0518

GRAVY Index0.06

Hydrophobic Moment 0.28

Boman Index0.14

Instability Index37.55

Aliphatic Index 63.50

Aromaticity 0.1500

Extinction Coeff. Reduced 1490.00

Extinction Coeff. Oxidized 1615.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 922.47

LogP -9.53

H-bond Donors 34.0

H-bond Acceptors 33.0

Rotatable Bonds 68.0

Heavy Atoms 163.0

Ring Count 7.0

Amide Bonds 21.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0149845 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitystereochemistry not specified [Other]

Bio-Activity Profile

Function

Antimicrobial Antibacterial

Targetrecombinant Escherichia coli surface-display screening

MethodSLAY screening

PaperAshley T Tucker, Sean P Leonard, Cory D DuBois, Gregory A Knauf, Ashley L Cunningham, Claus O Wilke, M Stephen Trent, Bryan W Davies. Discovery of Next-Generation Antimicrobials through Bacterial Self-Screening of Surface-Displayed Peptide Libraries. Cell. 2018 Jan 25;172(3):618-628.e13. doi: 10.1016/j.cell.2017.12.009. Epub 2018 Jan 4. PMID29307492 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29307492/