Peptide Database

Peptide NameBactericidal permeability-increasing protein (BPI)

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibiotic activity

Venom / Toxin ▸ General toxin ▸ Cytotoxin

Standard StatusStandard

Sequence Length134 amino acids

Chemical FormulaC642H1046N180O182S9

DescriptionStandard

        MARGPDNTLQWATLVVLAAVGTAVTAATNPGVVARITQKGLDYACQQGVAVLQKELEKMKIPDMSGSVKMKPFGKGHYNFYSMDVRGFQLPSSQMKLLPDEGLGLSIRNANVKIGGKWKARKSFMCVSRLGVVD
    

Molecular Weight14486.85 Da

Isoelectric Point (pI)9.85

Net Charge (pH 7.0)8.57

Net Charge (pH 7.4) 8.24

Charge Density (pH 7.0) 0.0640

GRAVY Index-0.06

Hydrophobic Moment 0.65

Boman Index0.06

Instability Index30.43

Aliphatic Index 85.82

Aromaticity 0.0672

Extinction Coeff. Reduced 15470.00

Extinction Coeff. Oxidized 15595.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 5821.47

LogP -57.70

H-bond Donors 202.0

H-bond Acceptors 201.0

Rotatable Bonds 488.0

Heavy Atoms 1013.0

Ring Count 18.0

Amide Bonds 145.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0106380 VERIFIED: NO

Provenance & Taxonomy

OrganismEquus asinus asinus [Animal]

FamilyBPI

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Anti-Gram-negative Cytotoxin

TargetGram-negative bacteria

MethodQualitative functional evidence