Peptide Database

Peptide NameHD5[L16R]

Function Ontology

Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic

Antimicrobial

Antiviral

Antiviral ▸ Anti-Herpesvirus ▸ Anti-HSV

Antiviral ▸ Antiviral mechanism ▸ Viral entry inhibition

Antiviral ▸ Antiviral mechanism ▸ Viral entry inhibition ▸ Entry inhibitor

Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic

Venom / Toxin ▸ General toxin ▸ Cytotoxic

Standard StatusStandard

Sequence Length32 amino acids

Chemical FormulaC144H245N53O45S6

DescriptionStandard

        ATCYCRTGRCATRESRSGVCEISGRLYRLCCR
    

Molecular Weight3631.20 Da

Isoelectric Point (pI)9.22

Net Charge (pH 7.0)4.74

Net Charge (pH 7.4) 4.46

Charge Density (pH 7.0) 0.1481

GRAVY Index-0.37

Hydrophobic Moment 0.81

Boman Index-0.32

Instability Index33.54

Aliphatic Index 51.88

Aromaticity 0.0625

Extinction Coeff. Reduced 2980.00

Extinction Coeff. Oxidized 3355.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 1635.16

LogP -22.68

H-bond Donors 70.0

H-bond Acceptors 56.0

Rotatable Bonds 120.0

Heavy Atoms 248.0

Ring Count 2.0

Amide Bonds 31.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0006057 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configcyclic/stapled peptide [Cyclic]

Chiralitycanonical L-amino-acid peptide [L]

N-TermNone

C-TermNone

Disulfide3-31, 5-20, 10-30

Bio-Activity Profile

Function

Antimicrobial Antiviral

TargetHerpes simplex virus2(HSV-2):Potential for CaSki cell protection from HSV-2 infection(51.2% ± 7.2% cell protection at 100 μg/ml)

RECORD: Rec_0022630 VERIFIED: YES

Provenance & Taxonomy

OrganismHomo sapiens [Animal]

FamilyDefensin

Tax ID9606;0

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Other ModsSequence-variant derivative

Bio-Activity Profile

Function

Antiviral Entry inhibitor

TargetHerpes simplex virus 2 (Virus entry); CaSki

Activity18.451111 μM

MethodPlaque assay

PaperEnhancement of antiviral activity of human alpha-defensin 5 against herpes simplex virus 2 by arginine mutagenesis at adaptive evolution sites. | Wang A, Chen F, Wang Y, Shen M, Xu Y, Hu J, Wang S, Geng F, Wang C, Ran X, Su Y, Cheng T, Wang J. | J Virol. 2013 | PMID:23269800 PMID23269800 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/23269800/

RECORD: Rec_0070825 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

FamilyDefensin

Tax ID32630

Structure & Mods

Configdisulfide-constrained cyclic peptide [Cyclic]

Chiralitycanonical L-amino-acid peptide [L]

N-TermNone

C-TermNone

Disulfide3-31, 5-20, 10-30

Other ModsDisulfide bonds between Cys3 and Cys31,Cys5 and Cys20,Cys10 and Cys30.

Bio-Activity Profile

Function

Antiviral Anti-HSV Entry inhibition

Targetneutralization activity against HSV-2 during the preinfection stage

Activity18.45 μM

MethodIC50

Half-LifeMammalian: 4.4 h; Yeast: >20 h; E. coli: >10 h

PaperEnhancement of antiviral activity of human alpha-defensin 5 against herpes simplex virus 2 by arginine mutagenesis at adaptive evolution sites. | Wang A, Chen F, Wang Y, Shen M, Xu Y, Hu J, Wang S, Geng F, Wang C, Ran X, Su Y, Cheng T, Wang J. | J Virol. 2013 Mar;87(5):2835-45. | DOI:10.1128/JVI.02209-12 | PMID:23269800 PMID23269800 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/23269800/

RECORD: Rec_0086612 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

FamilyDefensin

Tax ID32630

Structure & Mods

Configdisulfide-constrained cyclic peptide [Cyclic]

Chiralitycanonical L-amino-acid peptide [L]

N-TermNone

C-TermNone

Disulfide3-31, 5-20, 10-30

Other ModsDisulfide bonds between Cys3 and Cys31,Cys5 and Cys20,Cys10 and Cys30.

Bio-Activity Profile

Function

Antiviral Anti-HSV Entry inhibition

TargetHerpes simplex virus2 (HSV-2) | CaSki cell

Activity100 μg/mL

Method% inhibition

Half-LifeMammalian: 4.4 h; Yeast: >20 h; E. coli: >10 h

PaperEnhancement of antiviral activity of human alpha-defensin 5 against herpes simplex virus 2 by arginine mutagenesis at adaptive evolution sites. | Wang A, Chen F, Wang Y, Shen M, Xu Y, Hu J, Wang S, Geng F, Wang C, Ran X, Su Y, Cheng T, Wang J. | J Virol. 2013 Mar;87(5):2835-45. | DOI:10.1128/JVI.02209-12 | PMID:23269800 PMID23269800 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/23269800/

RECORD: Rec_0105741 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configcyclic/stapled peptide [Cyclic]

Chiralitycanonical L-amino-acid peptide [L]

N-TermNone

C-TermNone

Disulfide3-31, 5-20, 10-30

Bio-Activity Profile

Function

Antimicrobial Antiviral

TargetCaSki cells up to 100μg/ ml

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