Peptide Database

Peptide NameBactericidal permeability-increasing protein (BPI)

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibiotic activity

Venom / Toxin ▸ General toxin ▸ Cytotoxin

Standard StatusStandard

Sequence Length473 amino acids

Chemical FormulaC2328H3721N591O678S16

DescriptionStandard

        MFLWCVLVLVSLVSVATGTSAGVKVRLTQKGLEYGRQIGIASIQQKLRTIKVPDISGTEKVDPIGKVQYSFTGMQIVNLGLPKSALALVPDTGVILSIGNAYINLHGNWRVKYLRIIKDSGSFDLAVSELTISTTVAVTSDDTGRPTVSMTNCAATVGSVNVKFHGGASWLYNLFSSFINKALRNALQKQICPLVADSVADINPHLKTLNVLAKVDQYAEIEYSMVGSPVISNTSIDLGLKGEFYNIGQHKEPPFSPTPFSLPSQDTDMLYIGVSAFTINSAGFVYNRAGALRLYITDDMIPSGSPIRLNTKTFGGFIPQIEKMYPGLMMKLLVETVKEPLMTFEPNNMTVQASSTVTAYAIQPNSTLSPLFVLNLEGSVSTHIYVTELKLAGNVTLNKIDMSLAKSYVGPFQVTSLDNIFTIVLKFAVIPKVNARLQEGYPLPAIGKMQLVNSQLQVLKDYLLIGTDVQFTG
    

Molecular Weight51350.04 Da

Isoelectric Point (pI)8.83

Net Charge (pH 7.0)4.92

Net Charge (pH 7.4) 4.31

Charge Density (pH 7.0) 0.0104

GRAVY Index0.22

Hydrophobic Moment 0.72

Boman Index0.18

Instability Index31.05

Aliphatic Index 105.45

Aromaticity 0.0825

Extinction Coeff. Reduced 41830.00

Extinction Coeff. Oxidized 41955.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0229420 VERIFIED: NO

Provenance & Taxonomy

OrganismSinocyclocheilus grahami (Dianchi golden-line fish) [Animal]

FamilyBPI

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Anti-Gram-negative Cytotoxin

TargetGram-negative bacteria