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MYP_163244
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Basic Information
GBVA4(1-19)
Antimicrobial
Antiviral
Antiviral ▸ Anti-Hepatitis virus ▸ Anti-HCV
Antiviral ▸ Antiviral mechanism ▸ Viral entry inhibition
Antiviral ▸ Antiviral mechanism ▸ Viral entry inhibition ▸ Entry inhibitor
Standard
19 amino acids
C109H183N33O24S
Standard
Sequence
LLDCWVRLGRYLLRRLKTP
Physicochemical Analysis
2371.89 Da
10.85
3.75
3.53
0.1973
-0.04
0.92
-0.17
49.32
138.42
0.1053
6990.00
6990.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
945.50
-4.17
37.0
29.0
77.0
167.0
4.0
18.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0055863 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Antiviral
5
PaperScreening and rational design of hepatitis C virus entry inhibitory peptides derived from GB virus A NS5A. J Virol. 2013 Feb;87(3):1649-1657. doi: 10.1128/JVI.02201-12. PMID: 23175359. PMID23175359 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/23175359/
RECORD: Rec_0167862 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Antiviral
PaperScreening and rational design of hepatitis C virus entry inhibitory peptides derived from GB virus A NS5A. J Virol. 2013 Feb;87(3):1649-1657. doi: 10.1128/JVI.02201-12. PMID: 23175359. PMID23175359 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/23175359/
RECORD: Rec_0180534 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antiviral
Hepatitis C virus (HCV) JFH-1
90-100 % Inhibition
Inhibition
PMID23175359 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/23175359/
RECORD: Rec_0290680 VERIFIED: YES
Provenance & Taxonomy
Hepatitis C virus [Virus]
Virus-derived peptide
3052230;0
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antiviral Entry inhibitor
Hepatitis C virus (Virus entry); Huh7.5.1
3 μM
RT-PCR
PaperScreening and rational design of hepatitis C virus entry inhibitory peptides derived from GB virus A NS5A. | Liu X, Huang Y, Cheng M, Pan L, Si Y, Li G, Niu Y, Zhao L, Zhao J, Li X, Chen Y, Yang W. | J Virol. 2013 | PMID:23175359 PMID23175359 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/23175359/
RECORD: Rec_0296452 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Protein-derived synthetic peptide
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antiviral Anti-HCV Entry inhibition
Hepatitis C virus(Jc1-Luc HCVcc) | Huh7.5.1 cells
3 μM
IC50
Mammalian: 5.5 h; Yeast: 3 min; E. coli: 2 min
PaperScreening and rational design of hepatitis C virus entry inhibitory peptides derived from GB virus A NS5A. | Liu X, Huang Y, Cheng M, Pan L, Si Y, Li G, Niu Y, Zhao L, Zhao J, Li X, Chen Y, Yang W. | J Virol. 2013 Feb;87(3):1649-57. | DOI:10.1128/JVI.02201-12 | PMID:23175359 PMID23175359 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/23175359/
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