‹ ›
MYP_163235
← PREVIOUS NEXT → BACK
Basic Information
JEV(1962-1975)
Antimicrobial
Antiviral
Antiviral ▸ Anti-Flavivirus ▸ Anti-Japanese encephalitis virus
Antiviral ▸ Anti-Flavivirus ▸ Anti-West Nile virus
Antiviral ▸ Anti-Hepatitis virus ▸ Anti-HCV
Antiviral ▸ Antiviral mechanism ▸ Viral replication inhibition ▸ Replication inhibitor
Enzyme modulation ▸ Enzyme inhibition ▸ Helicase inhibition
Standard
14 amino acids
C62H109N29O20
Standard
Sequence
RRGRVGRNPNQVGD
Physicochemical Analysis
1580.71 Da
12.00
2.76
2.56
0.1975
-1.89
0.74
-0.69
27.99
41.43
0.0000
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
847.00
-13.04
30.0
23.0
53.0
111.0
1.0
16.0
Structural Visualization
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber in the current view mode. Use the buttons to zoom.
2D CHEMICAL STRUCTURE
Drag to move
Drag to move. Use the buttons to zoom.
Experimental Records
RECORD: Rec_0035419 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Antiviral
West Nile virus (WNV): inhibition of WNV helicase activity
215±7.2 μM
IC50
PaperPubMed PMID: 18479669 PMID18479669 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/18479669/
RECORD: Rec_0053408 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Protein-derived synthetic peptide
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antiviral Anti-WNV Helicase inhibition
West Nile virus (WNV)
215±7.2 μM
IC50
Mammalian: 1 h; Yeast: 2 min; E. coli: 2 min
PaperViral NS3 helicase activity is inhibited by peptides reproducing the Arg-rich conserved motif of the enzyme (motif VI). | Borowski P, Heising MV, Miranda IB, Liao CL, Choe J, Baier A. | Biochem Pharmacol. 2008 Jul 1;76(1):28-38. | DOI:10.1016/j.bcp.2008.03.018 | PMID:18479669 PMID18479669 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/18479669/
RECORD: Rec_0059055 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Protein-derived synthetic peptide
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antiviral Anti-HCV Helicase inhibition
Hepatitis C virus (HCV)
196±9.4 μM
IC50
Mammalian: 1 h; Yeast: 2 min; E. coli: 2 min
PaperViral NS3 helicase activity is inhibited by peptides reproducing the Arg-rich conserved motif of the enzyme (motif VI). | Borowski P, Heising MV, Miranda IB, Liao CL, Choe J, Baier A. | Biochem Pharmacol. 2008 Jul 1;76(1):28-38. | DOI:10.1016/j.bcp.2008.03.018 | PMID:18479669 PMID18479669 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/18479669/
RECORD: Rec_0064278 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antiviral Antimicrobial
PaperAVPdb: a database of experimentally validated antiviral peptides targeting medically important viruses PMID24285301 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/24285301/
RECORD: Rec_0162382 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Antiviral
PaperPubMed PMID: 18479669 PMID18479669 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/18479669/
1 2 3 NEXT LAST
Showing 5 records on this page · Page 1 of 3