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MYP_163187
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Basic Information
Brevinin-1SE
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antibiotic activity
Immunology ▸ Adverse immune reactivity ▸ Histamine-release modulation
Immunology ▸ Innate immune defense ▸ Host defense peptide ▸ Defense peptide
Immunology ▸ Innate immune modulation ▸ Mast cell modulation
Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic
Standard
23 amino acids
C111H193N31O26S2
Standard
Sequence
FLPLVRGAAKLIPSVVCAISKRC
Physicochemical Analysis
2442.04 Da
10.11
3.74
3.50
0.1625
1.05
0.67
0.22
28.16
135.65
0.0435
0.00
125.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
902.24
-6.16
34.0
32.0
78.0
170.0
3.0
22.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0076983 VERIFIED: YES
Provenance & Taxonomy
Lithobates sevosus [Animal]
Brevinin
Structure & Mods
Linear peptide with a single intramolecular disulfide-stabilized loop [Linear]
Gene-encoded natural peptide composed of standard L-amino acids [L]
17-23
Bio-Activity Profile
Antimicrobial Antibacterial Mast cell degranulation Histamine releasing
PaperC. Graham et al. / Peptides 27 (2006) 1313-1319. Histamine-releasing and antimicrobial peptides from the skin secretions of the dusky gopher frog, Rana sevosa Evidence URLhttps://www.uniprot.org/uniprotkb/P85056/entry
RECORD: Rec_0085036 VERIFIED: YES
Provenance & Taxonomy
Rana sevosa [Animal]
Brevinin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial
PaperHistamine-releasing and Antimicrobial Peptides From the Skin Secretions of the Dusky Gopher Frog, Rana Sevosa
RECORD: Rec_0128224 VERIFIED: YES
Provenance & Taxonomy
Rana sevosa [Animal]
Brevinin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Escherichia coli K12
PMID16386333 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/16386333/
RECORD: Rec_0138675 VERIFIED: YES
Provenance & Taxonomy
Rana sevosa [Animal]
Brevinin
Structure & Mods
topology not specified [Not included yet]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Micrococcus luteus NCT C2665
PaperPubMed PMID: 16386333 PMID16386333 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/16386333/
RECORD: Rec_0147670 VERIFIED: YES
Provenance & Taxonomy
Lithobates sevosus [Animal]
Brevinin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Defense peptide Antimicrobial Antibiotic Anti-Gram-negative Non-hemolytic
Micrococcus luteus (Gram-negative)
PMID16386333 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/16386333/
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