Peptide Database

Peptide NameUnnamed

Function Ontology

Antimicrobial

Antiviral

Antiviral ▸ Anti-HIV

Antiviral ▸ Anti-Pneumovirus ▸ Anti-RSV

Antiviral ▸ Antiviral mechanism ▸ Viral entry inhibition ▸ Entry inhibitor

Antiviral ▸ Antiviral mechanism ▸ Viral fusion inhibition ▸ Fusion inhibitor

Standard StatusStandard

Sequence Length35 amino acids

Chemical FormulaC191H301N49O63S

DescriptionStandard

        EWERKVDFLEENITALLEEAQIQQEKNMYELQKLN
    

Molecular Weight4323.79 Da

Isoelectric Point (pI)4.34

Net Charge (pH 7.0)-5.15

Net Charge (pH 7.4) -5.33

Charge Density (pH 7.0) -0.1470

GRAVY Index-0.99

Hydrophobic Moment 0.50

Boman Index-0.18

Instability Index50.23

Aliphatic Index 92.00

Aromaticity 0.0857

Extinction Coeff. Reduced 6990.00

Extinction Coeff. Oxidized 6990.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 1886.26

LogP -14.32

H-bond Donors 61.0

H-bond Acceptors 59.0

Rotatable Bonds 154.0

Heavy Atoms 304.0

Ring Count 4.0

Amide Bonds 41.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0352839 VERIFIED: YES

Provenance & Taxonomy

OrganismSimian immunodeficiency virus [Virus]

FamilyVirus-derived peptide

Tax ID11723;0

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antiviral Entry inhibitor Fusion inhibitor

TargetSimian immunodeficiency virus (gp160)

MethodCell-fusion assay

PaperFusion proteins comprising DP-178 and other viral fusion inhibitor peptides useful for treating aids | Dani Paul Bolognesi, Thomas James Matthews, Carl T. Wild, Durham, Shawn O'Lin Barney, Dennis Michael Lambert, Stephen Robert Petteway, Alphonse J. Langlois | Duke University, Durham, NC (US) | Patent:US7122190 Evidence URLhttps://patents.google.com/patent/US7122190/en PatentUS7122190

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