Peptide Database

Peptide NameBactericidal permeability-increasing protein (BPI)

Function Ontology

Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Venom / Toxin ▸ General toxin ▸ Cytotoxic

Standard StatusStandard

Sequence Length472 amino acids

Chemical FormulaC2377H3772N610O664S14

DescriptionStandard

        DKGEKMLKTWYSFLLCWLSLGLEANPGLKLRITQKGLDYGRRIGVELLKQAVLKETFPSWSGQESFSVVKVNYVISRLRINAVDFPETSASFIPGTGISLSVAHASATISADWIMNTWLLKDQGGITVSVSGLFIAVIFKVSRDSAGHLSILLQNCQLSINSVKVKLNGGSSWIYSFLSGYLEKPIHTKLDKNLCLNIKYKIQMMDAQLRKHKVLSRIDAFAQIDYSLVSSPEVFKSHINLDLKGTVYPAGNHTDPPFVPAPFALPDQGDSMLYLGVSSYFLKSASLAYYRAGALNIIIFEELATTFNLRSALFKDFVPETALNYVTACPVLLKLMATSPPAVTLNAGRCILQITGCVEVFAVLPNSTTQYIFSGNLTASTRANLTITKQKLIISLLLKRFQFSLLHSTVGASEMSLMENFLSYALRSAVIPVINDKLGRGFPLNLAHTTLTGPVIKINQGHLVISTDIHYK
    

Molecular Weight51967.97 Da

Isoelectric Point (pI)9.37

Net Charge (pH 7.0)14.58

Net Charge (pH 7.4) 13.68

Charge Density (pH 7.0) 0.0309

GRAVY Index0.23

Hydrophobic Moment 0.72

Boman Index0.17

Instability Index31.41

Aliphatic Index 108.67

Aromaticity 0.0953

Extinction Coeff. Reduced 56840.00

Extinction Coeff. Oxidized 57215.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0205891 VERIFIED: NO

Provenance & Taxonomy

OrganismBuceros rhinoceros silvestris [Animal]

FamilyBPI/LBP

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antimicrobial Anti-Gram-negative Cytotoxic Non-hemolytic

TargetGram-negative bacteria