Peptide Database

Peptide NameTrastuzumab

Function Ontology

Anticancer

Immunology ▸ Immunomodulation ▸ Immunotherapy

Standard StatusStandard

Sequence Length224 amino acids

Chemical FormulaC1072H1668N288O351S6

DescriptionStandard

        DIQMTQSPSSLSASVGDRVTITCRASQDVNTAVAWYQQKPGKAPKLLIYSASFLYSGVPSRFSGSRSGTDFTLTISSLQPEDFATYYCQQHYTTPPTFGQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGECEVQLVESGGG
    

Molecular Weight24398.82 Da

Isoelectric Point (pI)6.35

Net Charge (pH 7.0)-1.01

Net Charge (pH 7.4) -1.50

Charge Density (pH 7.0) -0.0045

GRAVY Index-0.43

Hydrophobic Moment 0.58

Boman Index-0.01

Instability Index54.41

Aliphatic Index 66.12

Aromaticity 0.0938

Extinction Coeff. Reduced 25900.00

Extinction Coeff. Oxidized 26150.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0319576 VERIFIED: YES

Provenance & Taxonomy

OrganismHomo sapiens [Animal]; Cricetulus griseus [Animal]

FamilyMonoclonal antibody

Tax ID9606;10029

Structure & Mods

Configlinear multidomain protein biologic [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Anticancer Immunotherapy Monoclonal antibody

Half-Lifeaverage 28.5 d

PaperPubMed-linked source references: PMID:21813259; PMID:14613027; PMID:14528282; PMID:12908564; PMID:25572781; PMID:25547504; PMID:25532690; PMID:25494663 PMID21813259;14613027;14528282;12908564;25572781;25547504;25532690;25494663 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/21813259/ PatentCA2103059