Peptide Database

Peptide NameBactericidal permeability-increasing protein

Function Ontology

Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibiotic activity

Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Venom / Toxin ▸ General toxin ▸ Cytotoxic

Standard StatusStandard

Sequence Length477 amino acids

Chemical FormulaC2350H3738N596O689S15

DescriptionStandard

        MVRADTLYLVLSVAVCVEAAAEAVKPGAIVRLTQKGLDYARQEGISVLQQQLSQIHLPDFSGSYDVGFLGNVDYRFSGLVISSVQLADSQVSLIPSVGLKLTISGAFIQIDGNWDVRYTFIHEDGSLNLKLMGVSISAGLILGSDTSGRPTISPADCSSHISNVEVHMSGTIGWLVDLFHGTVESALRQTMESQICPAVTESINTKLDPLLKTLPVIANIDHTSAIDYSLTGPPSVLTGWVDVQLKGEFFDVSHRTAPPFSAPEMPLPPEQGLMVYFGVSEYLFNTAAYVYQLAGALVFNLTDDMIPKDSIIRLNTSFLGTLIPQVLKMYPDMLVKLKMSSPSVQALKIKPDNLTMWPVVDVQAFAILPNSSLASLFLIQLTTNATAKVALDSGRIIGNLDLGRVETKLVHSDVGPFSVSLLNEIANYCVSRILLPRLNVILKKGLPLPLIDHVEITDSVLQTYEHYLLFGANVRYV
    

Molecular Weight51845.37 Da

Isoelectric Point (pI)5.19

Net Charge (pH 7.0)-12.62

Net Charge (pH 7.4) -13.50

Charge Density (pH 7.0) -0.0265

GRAVY Index0.31

Hydrophobic Moment 0.70

Boman Index0.20

Instability Index32.11

Aliphatic Index 114.38

Aromaticity 0.0755

Extinction Coeff. Reduced 44350.00

Extinction Coeff. Oxidized 44600.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0072152 VERIFIED: NO

Provenance & Taxonomy

OrganismHymenochirus boettgeri [Animal]

FamilyBPI/LBP

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Anti-Gram-negative Cytotoxic Non-hemolytic Non-ribosomal

TargetGram-negative bacteria

MethodQualitative functional evidence