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MYP_162905
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Basic Information
P5(ACE2 (4-39))
Antimicrobial
Antiviral
Antiviral ▸ Anti-Coronavirus ▸ Anti-SARS-CoV
Antiviral ▸ Antiviral mechanism ▸ Viral entry inhibition
Membrane / Ion-channel modulation ▸ Sodium channel modulation ▸ Sodium channel inhibitor
Standard
36 amino acids
C192H275N47O67
Standard
Sequence
EEQAKTFLDKFNHEAEDLFYQSSLASWNYNTNITEE
Physicochemical Analysis
4313.51 Da
4.29
-6.06
-6.30
-0.1683
-1.06
0.54
-0.11
80.66
51.67
0.1667
8480.00
8480.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1897.11
-19.53
63.0
62.0
143.0
306.0
8.0
41.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0135029 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Antiviral
SARS-CoV:inhibition of pseudovirus infection in HeLa cells
6 μM
IC50
PMID16510163 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/16510163/
RECORD: Rec_0237394 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Protein-derived synthetic peptide
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antiviral Anti-SARS-CoV Entry inhibition
SARS-CoV | HeLa cells
6 μM
IC50
Mammalian: 1 h; Yeast: 30 min; E. coli: >10 h
PaperIdentification of critical determinants on ACE2 for SARS-CoV entry and development of a potent entry inhibitor. | Han DP, Penn-Nicholson A, Cho MW. | Virology. 2006 Jun 20;350(1):15-25. | DOI:10.1016/j.virol.2006.01.029 | PMID:16510163 PMID16510163 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/16510163/
RECORD: Rec_0272600 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antiviral
SARS-CoV PsV
PMID16510163 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/16510163/
RECORD: Rec_0278159 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Antiviral
PMID16510163 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/16510163/
RECORD: Rec_0316451 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antiviral
Vesicular Stomatitis Virus (VSV) PsV
PMID16510163 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/16510163/
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