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MYP_162726
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Basic Information
K4-S4(1-16)
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antiviral
Antiviral ▸ Anti-HIV ▸ Anti-HIV-1
Enzyme modulation ▸ Enzyme inhibition ▸ Infection inhibition
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Toxic
Venom / Toxin ▸ General toxin ▸ Toxicity
Standard
16 amino acids
C86H152N22O18
Standard
Sequence
ALWKTLLKKVLKAAAK
Physicochemical Analysis
1782.26 Da
10.60
4.79
4.60
0.2994
0.34
0.70
0.07
8.26
140.62
0.0625
5500.00
5500.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
665.94
-1.66
24.0
23.0
63.0
126.0
2.0
15.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0009439 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Dermaseptin
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Staphylococcus aureus
PMID11850249 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/11850249/
RECORD: Rec_0026421 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Dermaseptin
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Antiviral Anti-HIV-1 Infection inhibition
Human immunodeficiency virus type 1 (HIV-1) | P4-CCR5 cells
28 μM
IC50
Mammalian: 4.4 h; Yeast: >20 h; E. coli: >10 h
PaperThe antimicrobial peptide dermaseptin S4 inhibits HIV-1 infectivity in vitro. | Lorin C, Saidi H, Belaid A, Zairi A, Baleux F, Hocini H, Bélec L, Hani K, Tangy F. | Virology. 2005 Apr 10;334(2):264-75. | DOI:10.1016/j.virol.2005.02.002 | PMID:15780876 PMID15780876 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/15780876/
RECORD: Rec_0037642 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Dermaseptin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Antimicrobial
Human erythrocytes
10±0.5 μM
LC50
Paperhttps://pubmed.ncbi.nlm.nih.gov/10660589/ PMID10660589 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/10660589/
RECORD: Rec_0064153 VERIFIED: YES
Provenance & Taxonomy
Synthetic construct [Synthetic]
Dermaseptin
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antiviral Toxicity
Hep-2 Cells
68.9 μg/mL
LC50
PaperEvaluation of the Antibacterial Activity of New Dermaseptin Derivatives against Acinetobacter baumannii.
RECORD: Rec_0108879 VERIFIED: YES
Provenance & Taxonomy
Synthetic construct [Synthetic]
Dermaseptin
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antiviral
Acinetobacter baumannii
6.25 μg/mL
MIC
PaperEvaluation of the Antibacterial Activity of New Dermaseptin Derivatives against Acinetobacter baumannii.
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