Peptide Database

Peptide NameBactericidal permeability-increasing protein (BPI)

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibiotic activity

Venom / Toxin ▸ General toxin ▸ Cytotoxin

Standard StatusStandard

Sequence Length465 amino acids

Chemical FormulaC2289H3643N579O665S21

DescriptionStandard

        MSPCCWLALLALVPFALATNPGVKVKLTEKGIEYGKQIGMASLQQKLKTMKVPDLSGTERVAPIGKVKYSLTGITIVNLGLPYSALALVPDTGISLSITNAFISLHGNWKIRYLSFIKDSGSFDLEVNGLTVTDSITIKSDETGRPTVSSVNCVANVGSASIKFHGGASWLYNLFSAYIDKALRSALQKQICPLVADTITDMNPHLKTLNVLAKVDKYAEVEYSMVTSPTISNASIDFSLKGEFYNIGKHQEPPFSPTPFSLPPQVNNMLYIGMSAFTTNSAGFVYNNAGALSLYITDDMIPPSSPIRLNTRTFGAFIPEIAKRFPSMMMKLLVKTVKEPTIFFEPNNVTVQASGSVTAYAIQPNTTLSPLFVLNMEGSVSARLYVTGVKLAGAVTLNKIEMTLETSYVGQFQVRMTFRACNLNITSRLEKGFPLPSIGKMNLVNTQLQVLKDYMLIGTDVQFTG
    

Molecular Weight50587.25 Da

Isoelectric Point (pI)9.11

Net Charge (pH 7.0)8.82

Net Charge (pH 7.4) 8.22

Charge Density (pH 7.0) 0.0190

GRAVY Index0.15

Hydrophobic Moment 0.70

Boman Index0.16

Instability Index31.44

Aliphatic Index 96.43

Aromaticity 0.0882

Extinction Coeff. Reduced 40340.00

Extinction Coeff. Oxidized 40590.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0109019 VERIFIED: NO

Provenance & Taxonomy

OrganismOncorhynchus mykiss [Animal]

FamilyBPI

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Anti-Gram-negative Cytotoxin

TargetGram-negative bacteria

MethodQualitative functional evidence