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MYP_162609
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Basic Information
p2(gag) peptide[Δ10-14]
Antimicrobial
Antiviral
Antiviral ▸ Anti-HIV
Enzyme modulation ▸ Enzyme inhibition ▸ Maturation inhibitor
Enzyme modulation ▸ Enzyme inhibition ▸ Protease inhibition
Standard
9 amino acids
C37H63N11O16S
Standard
Sequence
AEAMSQVTN
Physicochemical Analysis
950.03 Da
4.05
-1.20
-1.39
-0.1335
-0.26
0.43
0.04
44.60
54.44
0.0000
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
460.06
-6.90
15.0
16.0
31.0
65.0
0.0
10.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0007968 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Antiviral
HIV:inhibition of protease activity in CEM/LAV-1 cells
5 μM
IC50
PMID15113844 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/15113844/
RECORD: Rec_0049861 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antiviral
HIV-1
PMID15113844 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/15113844/
RECORD: Rec_0218999 VERIFIED: YES
Provenance & Taxonomy
Human immunodeficiency virus 1 [Virus]
11676
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antiviral Maturation inhibitor Protease inhibition
CEM/LAV-1
5 μM
IC50
PaperBlocking of human immunodeficiency virus type-1 virion autolysis by autologous p2(gag) peptide. PMID15113844 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/15113844/
RECORD: Rec_0232811 VERIFIED: YES
Provenance & Taxonomy
Human immunodeficiency virus 1 [Virus]
11676
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antiviral Protease inhibition
Qualitative inhibition
PaperThe p2 Peptide, AEAMSQVTNTATIM, Processed from HIV-1 Pr55gag Was Found to Be a Suicide Inhibitor of HIV-1 Protease. PMID9425262 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/9425262/
RECORD: Rec_0307793 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Synthetic peptide
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antiviral Anti-HIV
HIV | CEM/LAV-1 cells
5 μM
IC50
Mammalian: 4.4 h; Yeast: >20 h; E. coli: >10 h
PaperBlocking of human immunodeficiency virus type-1 virion autolysis by autologous p2(gag) peptide. | Misumi S, Morikawa Y, Tomonaga M, Ohkuma K, Takamune N, Shoji S. | J Biochem. 2004 Mar;135(3):447-53. | DOI:10.1093/jb/mvh052 | PMID:15113844 PMID15113844 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/15113844/
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