Peptide Database

Peptide NameRituximab

Function Ontology

Anticancer

Immunology ▸ Immunomodulation ▸ Immunotherapy

Standard StatusStandard

Sequence Length242 amino acids

Chemical FormulaC1134H1745N295O356S10

DescriptionStandard

        QVQLQQPGAELVKPGASVKMSCKASGYTFTSYNMHWVKQTPGRGLEWIGAIYPGNGDTSYNQKFKGKATLTADKSSSTAYMQLSSLTSEDSAVYYCARSTYYGGDWYFNVWGAGTTVTVSAASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGP
    

Molecular Weight25527.40 Da

Isoelectric Point (pI)8.87

Net Charge (pH 7.0)6.03

Net Charge (pH 7.4) 5.47

Charge Density (pH 7.0) 0.0249

GRAVY Index-0.27

Hydrophobic Moment 0.53

Boman Index0.09

Instability Index43.85

Aliphatic Index 62.02

Aromaticity 0.0992

Extinction Coeff. Reduced 46870.00

Extinction Coeff. Oxidized 47245.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0224799 VERIFIED: YES

Provenance & Taxonomy

OrganismHomo sapiens [Animal]; Mus musculus [Animal]

FamilyMonoclonal antibody

Tax ID9606;10090

Structure & Mods

Configlinear multidomain protein biologic [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Anticancer Immunotherapy Monoclonal antibody

Half-Life0.8 h (mammalian reticulocytes, in vitro)

PaperPubMed-linked source references: PMID:21813259; PMID:16705086; PMID:15795920; PMID:15201414; PMID:12826649; PMID:9704735; PMID:25609919; PMID:25573987; PMID:25586272 PMID21813259;16705086;15795920;15201414;12826649;9704735;25609919;25573987;25586272 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/21813259/ PatentCA2149329