Peptide Database

Peptide NameToxin CsEv1

Function Ontology

Immunology ▸ Innate immune defense ▸ Host defense peptide ▸ Host defense activity

Membrane / Ion-channel modulation ▸ Ion channel inhibition

Membrane / Ion-channel modulation ▸ Sodium channel modulation ▸ Sodium channel inhibitor

Venom / Toxin ▸ General toxin ▸ Toxin

Venom / Toxin ▸ Toxin

Standard StatusStandard

Sequence Length65 amino acids

Chemical FormulaC322H471N81O99S8

DescriptionStandard

        KEGYLVKKSDGCKYDCFWLGKNEHCDTECKAKNQGGSYGYCYAFACWCEGLPESTPTYPLPNKSC
    

Molecular Weight7317.19 Da

Isoelectric Point (pI)6.72

Net Charge (pH 7.0)-0.23

Net Charge (pH 7.4) -0.63

Charge Density (pH 7.0) -0.0035

GRAVY Index-0.77

Hydrophobic Moment 0.35

Boman Index-0.06

Instability Index55.84

Aliphatic Index 33.08

Aromaticity 0.1538

Extinction Coeff. Reduced 19940.00

Extinction Coeff. Oxidized 20440.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 2892.73

LogP -29.42

H-bond Donors 106.0

H-bond Acceptors 108.0

Rotatable Bonds 233.0

Heavy Atoms 510.0

Ring Count 17.0

Amide Bonds 68.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0249595 VERIFIED: YES

Provenance & Taxonomy

OrganismCentruroides sculpturatus [Animal]

FamilySodium channel inhibitor family

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

C-TermAmidation

Disulfide12-65; 16-41; 25-46; 29-48

Bio-Activity Profile

Function

Toxin Venom Sodium channel inhibitor family Ion channel inhibitor Host defense