Peptide Database

Peptide NameBactericidal permeability-increasing protein (BPI)

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibiotic activity

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Venom / Toxin ▸ General toxin ▸ Cytotoxin

Standard StatusStandard

Sequence Length476 amino acids

Chemical FormulaC2410H3794N608O666S16

DescriptionStandard

        MARGPDTARRWATLVVLAALSTAVTTTNPGIVARITQKGLDYACQQGVLTLQKELEKITIPNFSGNFKIKYLGKGQYSFFSMVIQGFNLPNSQIRPLPDKGLDLSIRDASIKIRGKWKARKNFIKLGGNFDLSVEGISILAGLNLGYDPASGHSTVTCSSCSSGINTVRIHISGSSLGYDLLGLWMGGGMNVYICEVVTSTVSSKLQPYFQTLPVTTKLDKVAGVDYSLVAPPRATANNLDWLLKGEFFSLAHRSPPPFAPPALAFPSDHDRMVYLGISEYFFNTAGFVYQKAGALNLTLRDDMIPKESKFRLTTKFFGILIPQVAKMFPDMQMQLFIWASLPPKLTMKPSGLDLIFVLDTQAFAILPNSSLDPLFLLEMNLNLSVVVGAKSDRLIGELRLDKLLLELKHSDIGPFSVESLQSVINYVMPTIVLPVINKKLQKGFPLPLPAYIELFNLTLQPYQDFLLFGADVHYS
    

Molecular Weight52454.62 Da

Isoelectric Point (pI)9.16

Net Charge (pH 7.0)9.00

Net Charge (pH 7.4) 8.32

Charge Density (pH 7.0) 0.0189

GRAVY Index0.16

Hydrophobic Moment 0.69

Boman Index0.16

Instability Index32.58

Aliphatic Index 103.24

Aromaticity 0.1008

Extinction Coeff. Reduced 49850.00

Extinction Coeff. Oxidized 50100.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0301770 VERIFIED: NO

Provenance & Taxonomy

OrganismBos taurus [Animal]

FamilyBPI

Tax ID9913

Structure & Mods

Configlinear polypeptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Anti-Gram-negative Cytotoxin Non-hemolytic

TargetGram-negative bacteria

MethodQualitative functional evidence