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MYP_162439
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Basic Information
ACE2 (4-26)
Antimicrobial
Antiviral
Antiviral ▸ Anti-Coronavirus ▸ Anti-SARS-CoV
Antiviral ▸ Antiviral mechanism ▸ Viral entry inhibition
Membrane / Ion-channel modulation ▸ Sodium channel modulation ▸ Sodium channel inhibitor
Standard
23 amino acids
C124H178N30O43
Standard
Sequence
EEQAKTFLDKFNHEAEDLFYQSS
Physicochemical Analysis
2776.92 Da
4.35
-4.07
-4.30
-0.1769
-1.15
0.54
-0.17
83.81
42.61
0.1739
1490.00
1490.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1218.23
-11.72
40.0
40.0
94.0
197.0
5.0
25.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0034363 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antiviral
SARS-CoV PsV
PMID16510163 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/16510163/
RECORD: Rec_0224714 VERIFIED: YES
Provenance & Taxonomy
Homo sapiens [Animal]
ACE2-derived peptide
9606
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antiviral
Severe acute respiratory syndrome coronavirus
50 μM
IC50
PaperIdentification of critical determinants on ACE2 for SARS-CoV entry and development of a potent entry inhibitor PMID16510163 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/16510163/
RECORD: Rec_0225959 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Antiviral
PMID16510163 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/16510163/
RECORD: Rec_0286292 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antiviral
Vesicular Stomatitis Virus (VSV) PsV
PMID16510163 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/16510163/
RECORD: Rec_0287480 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Protein-derived synthetic peptide
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antiviral Anti-SARS-CoV Entry inhibition
SARS-CoV | HeLa cells
50 μM
IC50
Mammalian: 1 h; Yeast: 30 min; E. coli: >10 h
PaperIdentification of critical determinants on ACE2 for SARS-CoV entry and development of a potent entry inhibitor. | Han DP, Penn-Nicholson A, Cho MW. | Virology. 2006 Jun 20;350(1):15-25. | DOI:10.1016/j.virol.2006.01.029 | PMID:16510163 PMID16510163 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/16510163/
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