Peptide Database

Peptide NameSLAY-screened peptide P4906

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Standard StatusStandard

Sequence Length20 amino acids

Chemical FormulaC130H197N35O24

DescriptionStandard

        TPLLWLWARTRPRFRKYIFI
    

Molecular Weight2634.18 Da

Isoelectric Point (pI)12.00

Net Charge (pH 7.0)4.40

Net Charge (pH 7.4) 4.20

Charge Density (pH 7.0) 0.2198

GRAVY Index-0.09

Hydrophobic Moment 0.46

Boman Index-0.03

Instability Index37.70

Aliphatic Index 102.50

Aromaticity 0.2500

Extinction Coeff. Reduced 12490.00

Extinction Coeff. Oxidized 12490.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 964.53

LogP -1.30

H-bond Donors 37.0

H-bond Acceptors 29.0

Rotatable Bonds 79.0

Heavy Atoms 189.0

Ring Count 9.0

Amide Bonds 19.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0064613 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitystereochemistry not specified [Other]

Bio-Activity Profile

Function

Antimicrobial Antibacterial

Targetrecombinant Escherichia coli surface-display screening

MethodSLAY screening

PaperAshley T Tucker, Sean P Leonard, Cory D DuBois, Gregory A Knauf, Ashley L Cunningham, Claus O Wilke, M Stephen Trent, Bryan W Davies. Discovery of Next-Generation Antimicrobials through Bacterial Self-Screening of Surface-Displayed Peptide Libraries. Cell. 2018 Jan 25;172(3):618-628.e13. doi: 10.1016/j.cell.2017.12.009. Epub 2018 Jan 4. PMID29307492 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29307492/