Peptide Database

Peptide NameIslet amyloid polypeptide

Function Ontology

Hormonal / Endocrine ▸ Hormone peptide

Neurological / Signaling ▸ Neuropeptide activity ▸ Neuropeptide

Regulatory peptide ▸ Biological regulation

Standard StatusStandard

Sequence Length37 amino acids

Chemical FormulaC166H267N51O55S2

DescriptionStandard

        KCNTATCATQRLANFLVHSNNNLGPVLSPTNVGSNTY
    

Molecular Weight3921.33 Da

Isoelectric Point (pI)8.90

Net Charge (pH 7.0)1.83

Net Charge (pH 7.4) 1.54

Charge Density (pH 7.0) 0.0493

GRAVY Index-0.26

Hydrophobic Moment 0.48

Boman Index0.03

Instability Index9.76

Aliphatic Index 73.78

Aromaticity 0.0541

Extinction Coeff. Reduced 1490.00

Extinction Coeff. Oxidized 1615.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 1736.73

LogP -25.98

H-bond Donors 60.0

H-bond Acceptors 60.0

Rotatable Bonds 123.0

Heavy Atoms 274.0

Ring Count 5.0

Amide Bonds 44.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0054691 VERIFIED: YES

Provenance & Taxonomy

OrganismCricetulus griseus [Animal]

FamilyIslet amyloid polypeptide

Tax ID10029

Structure & Mods

Configdisulfide-constrained peptide [Cyclic]

Chiralitycanonical L-amino-acid peptide [L]

C-TermAmidation

Disulfide2-7

Bio-Activity Profile

Function

Hormone Endocrine Metabolic regulation Physiological regulation

Half-LifeMammalian: 1.3 hour; Yeast: 3 min; E. coli: 2 min

RECORD: Rec_0094483 VERIFIED: YES

Provenance & Taxonomy

OrganismMesocricetus auratus [Animal]

FamilyIslet amyloid polypeptide

Tax ID10036

Structure & Mods

Configdisulfide-constrained peptide [Cyclic]

Chiralitycanonical L-amino-acid peptide [L]

C-TermAmidation

Disulfide2-7

Bio-Activity Profile

Function

Hormone Endocrine Metabolic regulation Physiological regulation

Half-LifeMammalian: 1.3 hour; Yeast: 3 min; E. coli: 2 min

RECORD: Rec_0096335 VERIFIED: YES

Provenance & Taxonomy

Organismnot reported [other]

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Neuropeptide

Paper数据库级溯源文献：Wang Y, Wang M, Yin S, et al. NeuroPep: a comprehensive resource of neuropeptides. Database (Oxford). 2015:bav038. PMID 25931458; Bin Y, Zhang W, Tang W, et al. Prediction of Neuropeptides from Sequence Information Using Ensemble Classifier and Hybrid Features. J Proteome Res. 2020;19(9):3732-3740. PMID 32786686. PMID25931458;32786686 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/25931458/

RECORD: Rec_0212895 VERIFIED: NO

Provenance & Taxonomy

OrganismMesocricetus auratus [Animal]

FamilyCalcitonin

Tax ID10036

Structure & Mods

Configdisulfide-constrained cyclic peptide [Cyclic]

Chiralitycanonical L-amino-acid peptide [L]

C-TermAmidation

Disulfide2-7

Bio-Activity Profile

Function

Hormone Calcium-regulatory peptide

RECORD: Rec_0243981 VERIFIED: YES

Provenance & Taxonomy

OrganismMesocricetus auratus [Animal]

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

-

TargetEscherichia coli TOP10

MethodMex pooled growth assay (OD_ID at 4.5 h; Wald adjusted p-value)

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