Peptide Database

Peptide NameSLAY-screened peptide P4077

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Standard StatusStandard

Sequence Length14 amino acids

Chemical FormulaC76H114N24O17S

DescriptionStandard

        ARLTAITHPMPHWH
    

Molecular Weight1667.93 Da

Isoelectric Point (pI)9.81

Net Charge (pH 7.0)1.06

Net Charge (pH 7.4) 0.72

Charge Density (pH 7.0) 0.0755

GRAVY Index-0.41

Hydrophobic Moment 0.34

Boman Index0.11

Instability Index48.09

Aliphatic Index 70.00

Aromaticity 0.0714

Extinction Coeff. Reduced 5500.00

Extinction Coeff. Oxidized 5500.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 628.23

LogP -3.76

H-bond Donors 22.0

H-bond Acceptors 22.0

Rotatable Bonds 46.0

Heavy Atoms 118.0

Ring Count 7.0

Amide Bonds 13.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0397762 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitystereochemistry not specified [Other]

Bio-Activity Profile

Function

Antimicrobial Antibacterial

Targetrecombinant Escherichia coli surface-display screening

MethodSLAY screening

PaperAshley T Tucker, Sean P Leonard, Cory D DuBois, Gregory A Knauf, Ashley L Cunningham, Claus O Wilke, M Stephen Trent, Bryan W Davies. Discovery of Next-Generation Antimicrobials through Bacterial Self-Screening of Surface-Displayed Peptide Libraries. Cell. 2018 Jan 25;172(3):618-628.e13. doi: 10.1016/j.cell.2017.12.009. Epub 2018 Jan 4. PMID29307492 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29307492/