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MYP_162225
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Basic Information
Kalata B1
Antimicrobial
Antiparasitic ▸ Anthelminthic
Antiparasitic ▸ Anthelminthic ▸ Nematicidal activity
Binding / Molecular interaction ▸ Binding activity
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Standard
30 amino acids
C123H190N36O43S6
Standard
Sequence
GLPTCGETCFGGTCNTPGCSCSSWPICTRN
Physicochemical Analysis
3053.43 Da
5.96
-0.30
-0.59
-0.0099
-0.08
0.23
0.11
44.29
26.00
0.0667
5500.00
5875.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1243.86
-20.47
49.0
49.0
89.0
208.0
6.0
31.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0183456 VERIFIED: YES
Provenance & Taxonomy
Oldenlandia affinis [Plant]
Cyclotide
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
-
Escherichia coli TOP10
Mex pooled growth assay (OD_ID at 4.5 h; Wald adjusted p-value)
PaperKoch P, Schmitt S, Cardner M, Beerenwinkel N, Panke S, Held M. Discovery of antimicrobials by massively parallelized growth assays (Mex). Scientific Reports. 2022;12:4097. doi:10.1038/s41598-022-07755-7 PMID35260685 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/35260685/
RECORD: Rec_0195194 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial
PaperPhytAMP: a database dedicated to antimicrobial plant peptides PMID18836196 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/18836196/
RECORD: Rec_0238488 VERIFIED: NO
Provenance & Taxonomy
Viola hederaceae [Plant]; Oldenlandia affinis [Plant]
Cyclotide
Structure & Mods
cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
5-19; 9-21; 14-27
Bio-Activity Profile
Antimicrobial Hemolytic
RECORD: Rec_0275018 VERIFIED: NO
Provenance & Taxonomy
Oldenlandia affinis [Plant]
Cyclotide
Structure & Mods
Backbone-cyclized cyclotide scaffold with cystine-knot family annotation [Cyclic]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial
Evidence URLhttps://camp.bicnirrh.res.in/seqDisp.php?id=CAMPSQ6415
RECORD: Rec_0316744 VERIFIED: YES
Provenance & Taxonomy
Viola hederacea [Plant]; Oldenlandia affinis [Plant]
Cyclic Peptide
60225
Structure & Mods
head-to-tail cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Nematocidal Anthelmintic Molluscicidal Membrane-Binding Antimicrobial Hemolytic
Human erythrocytes
7.7±1.3 μM
EC50
PaperPubMed PMID 1153582 | PubMed PMID 8153283 | PubMed PMID 4000000 PMID1153582;8153283;4000000;11535828;15328;34000 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/1153582/
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