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MYP_162205
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Basic Information
Unnamed
Anticancer
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antiparasitic ▸ Antimalarial
Antiparasitic ▸ Antiprotozoal
Antiparasitic ▸ Antiprotozoal ▸ Antimalarial ▸ Anti-Plasmodium
Antiparasitic ▸ General antiparasitic ▸ Antiparasitic
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Toxic
Venom / Toxin ▸ General toxin ▸ Toxin
Standard
28 amino acids
C116H203N41O35S7
Standard
Sequence
RCLPAGKTCVRGPMRVPCCGSCSQNKCT
Physicochemical Analysis
2956.56 Da
9.22
4.70
4.41
0.1678
-0.23
0.66
-0.17
58.94
38.21
0.0000
0.00
375.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1227.49
-18.45
49.0
47.0
94.0
199.0
3.0
29.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0210536 VERIFIED: YES
Provenance & Taxonomy
Psalmopoeus cambridgei [Animal]
Structure & Mods
DNA-encoded linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
-
Escherichia coli TOP10
Mex pooled growth assay (OD_ID at 4.5 h; Wald adjusted p-value)
PaperKoch P, Schmitt S, Cardner M, Beerenwinkel N, Panke S, Held M. Discovery of antimicrobials by massively parallelized growth assays (Mex). Scientific Reports. 2022;12:4097. doi:10.1038/s41598-022-07755-7 PMID35260685 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/35260685/
RECORD: Rec_0226729 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide; DSSP H 10.7%, E 7.1%, T 35.7%, C 46.4% [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antiparasitic Toxic Antimicrobial Antiplasmodial Hemolytic
PaperAPD2: the updated antimicrobial peptide database and its application in peptide design PMID18957441 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/18957441/
RECORD: Rec_0257316 VERIFIED: YES
Provenance & Taxonomy
Psalmopoeus cambridgei [Animal]
Psalmopeotoxin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antiparasitic
PaperFEBS Lett. 2004 Aug 13;572(1-3):109-17. | http://www.ncbi.nlm.nih.gov/pubmed/15304333 PMID15304333 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/15304333/
RECORD: Rec_0274977 VERIFIED: YES
Provenance & Taxonomy
Psalmopoeus cambridgei [Animal]
Structure & Mods
topology not specified [Not included yet]
canonical L-amino-acid peptide [L]
Disulfide bond(s) reported
Bio-Activity Profile
Antiplasmodial Cytotoxic
Plasmodium falciparum
1.15 μM
IC50
PaperPubMed PMID: 15304333 PMID15304333 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/15304333/
RECORD: Rec_0308389 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
None
2-19, 9-24, 18-29
Bio-Activity Profile
Antimicrobial Antiparasitic Antiplasmodial
PaperParaPep: a web resource for experimentally validated antiparasitic peptide sequences and their structures PMID24923818 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/24923818/
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