Peptide Database

Peptide Name[Y14W]cGm (Derived from Gm)

Function Ontology

Anticancer

Antimicrobial

Antimicrobial ▸ Antibacterial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive

Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic

Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic

Standard StatusStandard

Sequence Length18 amino acids

Chemical FormulaC92H154N36O22S4

DescriptionStandard

        GCRRLCYKQRCVTWCRGR
    

Molecular Weight2244.70 Da

Isoelectric Point (pI)10.16

Net Charge (pH 7.0)5.72

Net Charge (pH 7.4) 5.45

Charge Density (pH 7.0) 0.3177

GRAVY Index-0.87

Hydrophobic Moment 0.47

Boman Index-0.54

Instability Index32.43

Aliphatic Index 37.78

Aromaticity 0.1111

Extinction Coeff. Reduced 6990.00

Extinction Coeff. Oxidized 7240.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 992.88

LogP -10.91

H-bond Donors 43.0

H-bond Acceptors 32.0

Rotatable Bonds 74.0

Heavy Atoms 154.0

Ring Count 3.0

Amide Bonds 18.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0360580 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configbackbone-cyclized peptide [Cyclic]

Chiralitycanonical L-amino-acid peptide [L]

Disulfide2-15; 6-11

Other ModsHead-to-tail backbone cyclization

Bio-Activity Profile

Function

Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative

TargetStaphylococcus aureus ATCC 25923

Activity16 μM

MethodMIC

RECORD: Rec_0383246 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configbackbone-cyclized peptide [Cyclic]

Chiralitycanonical L-amino-acid peptide [L]

N-TermNo specific N-terminal

C-TermNo specific C-terminal

Disulfide2-15; 6-11

Other ModsHead-to-tail backbone cyclization

Bio-Activity Profile

Function

Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Anticancer

TargetStaphylococcus aureus ATCC 25923

Activity16 μM

MethodMIC

RECORD: Rec_0396281 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configbackbone-cyclized peptide [Cyclic]

Chiralitycanonical L-amino-acid peptide [L]

N-TermNo specific N-terminal

C-TermNo specific C-terminal

Disulfide2-15; 6-11

Other ModsHead-to-tail backbone cyclization

Bio-Activity Profile

Function

Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Anticancer Hemolytic

Targethuman red blood cells

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