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MYP_161971
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Basic Information
Pleurain-D4
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antifungal
Membrane / Ion-channel modulation ▸ Calcium channel modulation ▸ Calcium channel inhibitor
Standard
23 amino acids
C111H194N30O28S2
Standard
Sequence
FRSGILKLASKIPSVLCAVLKNC
Physicochemical Analysis
2461.04 Da
9.85
3.74
3.50
0.1625
0.87
0.57
0.19
24.46
135.65
0.0435
0.00
125.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
938.47
-7.57
35.0
34.0
83.0
171.0
2.0
23.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0006646 VERIFIED: YES
Provenance & Taxonomy
Rana pleuraden [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal Anti-Gram-positive Anti-Gram-negative
Candida albicans
25 μg/mL
MIC
PMID19028675 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/19028675/
RECORD: Rec_0031425 VERIFIED: YES
Provenance & Taxonomy
Babina pleuraden [Animal]
Brevinin
Structure & Mods
DNA-encoded linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
-
Escherichia coli TOP10
Mex pooled growth assay (OD_ID at 4.5 h; Wald adjusted p-value)
PaperKoch P, Schmitt S, Cardner M, Beerenwinkel N, Panke S, Held M. Discovery of antimicrobials by massively parallelized growth assays (Mex). Scientific Reports. 2022;12:4097. doi:10.1038/s41598-022-07755-7 PMID35260685 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/35260685/
RECORD: Rec_0035360 VERIFIED: YES
Provenance & Taxonomy
Rana pleuraden [Animal]
Structure & Mods
topology not specified [Not included yet]
stereochemistry not specified [Other]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antifungal
Bacillus subtilis
50 μg/mL
MIC
PMID19028675 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/19028675/
RECORD: Rec_0039366 VERIFIED: YES
Provenance & Taxonomy
Rana pleuraden [Animal]
Structure & Mods
topology not specified [Not included yet]
stereochemistry not specified [Other]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antifungal
Yeast: Candida albicans
25 μg/mL
MIC
PMID19028675 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/19028675/
RECORD: Rec_0051237 VERIFIED: YES
Provenance & Taxonomy
Nidirana pleuraden [Animal]
Pleurain
369511
Structure & Mods
Linear peptide with a single intramolecular disulfide-stabilized loop [Linear]
Gene-encoded natural peptide composed of standard L-amino acids [L]
17-23
Bio-Activity Profile
Antimicrobial Antibacterial
PaperX. Wang et al. / Peptides 28 (2007) 2069-2074. A new family of antimicrobial peptides from skin secretions of Rana pleuraden Evidence URLhttps://www.uniprot.org/uniprotkb/B5L1I4/entry
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