Peptide Database

Peptide NameBactericidal permeability-increasing protein (BPI)

Function Ontology

Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Venom / Toxin ▸ General toxin ▸ Cytotoxic

Standard StatusStandard

Sequence Length476 amino acids

Chemical FormulaC2325H3755N637O682S13

DescriptionStandard

        MGKRKGKKISFTDTEMKEANGDAHGTSNEAEASNKLVSIEDLKDPNGQQLMEDVNWFEANKDPQHISLAIPLPDTPIKPLPKKADWEMILVWCVLALLALVPVSTATNPGVQVKLTQKGLDYGRQLGVAALQQKFRTISIPDQSGKGRILIGKVEYSVTGIRIVNLQLPTSTVGLVSGTGVRLSIDNANIKAQGNWRVKYLRFIKASGSFDLTVSGVTISVNIAVNNDNSGRPSVSMTSCTANLRDVNVRFSGRLSWLYNLFRSFIERPIRNSLQAQICPLVAKSIPDINAELATLNVVAKVDNYVEIDYSMLGSPLISSESIELGLKGVFYNIGQRNKPPFSAKPFSLPSQNTNMLYIGLSAFTVNSAAFAYHNAGAFSFDITDDLLGGLFASRRAVVKLYPGLKMKLLVKTVKAPIITFEPNKVTVQISSTVMAHVIHQNNTLSPIFMLNLEASASARVNIDRLNLKASVTLNR
    

Molecular Weight51960.39 Da

Isoelectric Point (pI)9.59

Net Charge (pH 7.0)14.93

Net Charge (pH 7.4) 14.32

Charge Density (pH 7.0) 0.0314

GRAVY Index-0.02

Hydrophobic Moment 0.76

Boman Index0.07

Instability Index34.29

Aliphatic Index 100.97

Aromaticity 0.0693

Extinction Coeff. Reduced 42400.00

Extinction Coeff. Oxidized 42525.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0185112 VERIFIED: YES

Provenance & Taxonomy

OrganismTriplophysa tibetana [other]

FamilyBPI/LBP

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antimicrobial Anti-Gram-negative Cytotoxic Non-hemolytic

TargetGram-negative bacteria