Peptide Database

Peptide NameBactericidal permeability-increasing protein (BPI)

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibiotic activity

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Venom / Toxin ▸ General toxin ▸ Cytotoxin

Standard StatusStandard

Sequence Length475 amino acids

Chemical FormulaC2366H3735N591O679S16

DescriptionStandard

        MLPSLLVLLTLMPHAFAINPGIKASLSDKGLKYGSHVGASWLLEKTGQMVIPDVAGEIDIGIGTVHYWLTSMKISQINLPEPTVTFMEKVGIKVSMENLNVAVHGNWNTKFSFIKDGGTFDLAVINVGLSTVIQLGSDGKGHLSVANVQCSSSIGGIDASFHGGGSFIFQPFVHFFKSKILNQIQEKICPGIEKYVNDLESQLEKMQVSFQVNRNLSIELPLVLPPIIQSSDVEVDLKGVFYGARNHTDPPFAAGPFQLVQQSDLMLTVGLSEFTINSASFAYYSAGLLQILITDDMIPKASPFRLNTTSFGTLIPQLPKMYPNMLMLLRAYAAQTPTVSFHPDTTTLNVFVSTKAYGIKPNATYIPFFRLDMNATLSSKFFISDEKLSGSTALDNLTLTVGATEIGPFQTESLQKLLQIGIKSYLLPLLNKKLKDGIPLPTVHNVQWVNSMLKVNKGFVEIATDTKISLQAAKS
    

Molecular Weight51836.56 Da

Isoelectric Point (pI)7.15

Net Charge (pH 7.0)0.38

Net Charge (pH 7.4) -0.48

Charge Density (pH 7.0) 0.0008

GRAVY Index0.17

Hydrophobic Moment 0.63

Boman Index0.19

Instability Index29.73

Aliphatic Index 101.98

Aromaticity 0.0884

Extinction Coeff. Reduced 38390.00

Extinction Coeff. Oxidized 38515.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0426107 VERIFIED: NO

Provenance & Taxonomy

OrganismParamormyrops kingsleyae [Bacterium]

FamilyBPI

Tax ID1676925

Structure & Mods

Configlinear polypeptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Anti-Gram-negative Cytotoxin Non-hemolytic

TargetGram-negative bacteria

MethodQualitative functional evidence