Peptide Database

Peptide NameUnnamed

Function Ontology

Anticancer

Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic

Antimicrobial

Antiviral

Antiviral ▸ Anti-Influenza virus

Antiviral ▸ Antiviral mechanism ▸ Viral entry inhibition

Antiviral ▸ Antiviral mechanism ▸ Viral fusion inhibition ▸ Fusion inhibitor

Therapeutic / Biomedical activity ▸ Protective bioactivity ▸ Cell protection ▸ Cytoprotection

Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic

Venom / Toxin ▸ General toxin ▸ Cytotoxic

Standard StatusStandard

Sequence Length35 amino acids

Chemical FormulaC172H279N43O61

DescriptionStandard

        PNDITLNNSVALDPIDISIELNKAKSDLEESKEWI
    

Molecular Weight3925.31 Da

Isoelectric Point (pI)4.07

Net Charge (pH 7.0)-5.03

Net Charge (pH 7.4) -5.10

Charge Density (pH 7.0) -0.1437

GRAVY Index-0.46

Hydrophobic Moment 0.40

Boman Index-0.01

Instability Index39.56

Aliphatic Index 114.29

Aromaticity 0.0286

Extinction Coeff. Reduced 5500.00

Extinction Coeff. Oxidized 5500.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 1695.70

LogP -16.76

H-bond Donors 56.0

H-bond Acceptors 56.0

Rotatable Bonds 134.0

Heavy Atoms 276.0

Ring Count 4.0

Amide Bonds 38.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0376524 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

N-TermAcetylation

C-TermAmidation

Bio-Activity Profile

Function

Antimicrobial Antiviral Cytotoxic Anticancer

TargetNo significant cytotoxic against HEp2 cells

Activity100 μM

MethodCC50

RECORD: Rec_0407219 VERIFIED: YES

Provenance & Taxonomy

OrganismHuman parainfluenza virus 3 [Virus]

FamilyVirus-derived peptide

Tax ID11216;0

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antiviral Fusion inhibitor Cytoprotective

TargetHuman parainfluenza virus type 3 (Fusion); HEp2

Activity100 μM

MethodEC50

PaperPeptides from conserved regions of paramyxovirus fusion (F) proteins are potent inhibitors of viral fusion. | Lambert DM, Barney S, Lambert AL, Guthrie K, Medinas R, Davis DE, Bucy T, Erickson J, Merutka G, Petteway SR Jr. | Proc Natl Acad Sci U S A. 1996 | PMID:8700906 PMID8700906 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/8700906/

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