Peptide Database

Peptide NameSLAY-screened peptide P2857

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Standard StatusStandard

Sequence Length13 amino acids

Chemical FormulaC64H96N20O20

DescriptionStandard

        TAPSYPHINNHKS
    

Molecular Weight1465.57 Da

Isoelectric Point (pI)8.31

Net Charge (pH 7.0)0.57

Net Charge (pH 7.4) 0.28

Charge Density (pH 7.0) 0.0439

GRAVY Index-1.37

Hydrophobic Moment 0.17

Boman Index-0.14

Instability Index100.37

Aliphatic Index 37.69

Aromaticity 0.0769

Extinction Coeff. Reduced 1490.00

Extinction Coeff. Oxidized 1490.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 645.42

LogP -8.58

H-bond Donors 21.0

H-bond Acceptors 23.0

Rotatable Bonds 42.0

Heavy Atoms 104.0

Ring Count 5.0

Amide Bonds 14.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0104144 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitystereochemistry not specified [Other]

Bio-Activity Profile

Function

Antimicrobial Antibacterial

Targetrecombinant Escherichia coli surface-display screening

MethodSLAY screening

PaperAshley T Tucker, Sean P Leonard, Cory D DuBois, Gregory A Knauf, Ashley L Cunningham, Claus O Wilke, M Stephen Trent, Bryan W Davies. Discovery of Next-Generation Antimicrobials through Bacterial Self-Screening of Surface-Displayed Peptide Libraries. Cell. 2018 Jan 25;172(3):618-628.e13. doi: 10.1016/j.cell.2017.12.009. Epub 2018 Jan 4. PMID29307492 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29307492/