MYP_161868
B1-L-5
Anticancer
Toxicity / Safety
▸
Blood cell toxicity
▸
Hemolysis
▸
Hemolytic
Standard
15 amino acids
C94H158N26O17
Standard
VRRFKKFFSKLKKLV
1924.42 Da
12.00
6.73
6.51
0.4486
-0.33
0.90
-0.33
20.52
90.67
0.2000
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Amino Acid Composition
744.85
-2.52
28.0
24.0
70.0
137.0
3.0
14.0
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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RECORD: Rec_0037666
VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
hydrocarbon-stapled side-chain cyclic peptide [Cyclic]
noncanonical stereochemical modification [Modified]
None
Amidation
Stapled: Ⓧ(2) and Ⓧ (9) are cross-linked by hydrocarbon stapling
Bio-Activity Profile
Anticancer
MCF-7
13.99±0.73 μM
IC50
RECORD: Rec_0137171
VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
hydrocarbon-stapled side-chain cyclic peptide [Cyclic]
noncanonical stereochemical modification [Modified]
None
Amidation
Stapled: Ⓧ(2) and Ⓧ (9) are cross-linked by hydrocarbon stapling
Bio-Activity Profile
Hemolytic
human red blood cells
>80 μM
HC50
RECORD: Rec_0302425
VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
hydrocarbon-stapled side-chain cyclic peptide [Cyclic]
noncanonical stereochemical modification [Modified]
None
Amidation
Stapled: Ⓧ(2) and Ⓧ (9) are cross-linked by hydrocarbon stapling
Bio-Activity Profile
Anticancer
Huh-7
13.84±1.53 μM
IC50
RECORD: Rec_0356254
VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
hydrocarbon-stapled side-chain cyclic peptide [Cyclic]
noncanonical stereochemical modification [Modified]
None
Amidation
Stapled: Ⓧ(2) and Ⓧ (9) are cross-linked by hydrocarbon stapling
Bio-Activity Profile
Anticancer
U87
14.33±2.35 μM
IC50