Peptide Database

Peptide NameSLAY-screened peptide P4447

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Standard StatusStandard

Sequence Length20 amino acids

Chemical FormulaC105H166N32O28

DescriptionStandard

        LRILQPPSASYPHDFASRLR
    

Molecular Weight2324.64 Da

Isoelectric Point (pI)10.74

Net Charge (pH 7.0)1.85

Net Charge (pH 7.4) 1.59

Charge Density (pH 7.0) 0.0924

GRAVY Index-0.49

Hydrophobic Moment 0.46

Boman Index-0.13

Instability Index95.61

Aliphatic Index 88.00

Aromaticity 0.1000

Extinction Coeff. Reduced 1490.00

Extinction Coeff. Oxidized 1490.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 965.54

LogP -8.98

H-bond Donors 34.0

H-bond Acceptors 31.0

Rotatable Bonds 70.0

Heavy Atoms 165.0

Ring Count 6.0

Amide Bonds 20.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0252430 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitystereochemistry not specified [Other]

Bio-Activity Profile

Function

Antimicrobial Antibacterial

Targetrecombinant Escherichia coli surface-display screening

MethodSLAY screening

PaperAshley T Tucker, Sean P Leonard, Cory D DuBois, Gregory A Knauf, Ashley L Cunningham, Claus O Wilke, M Stephen Trent, Bryan W Davies. Discovery of Next-Generation Antimicrobials through Bacterial Self-Screening of Surface-Displayed Peptide Libraries. Cell. 2018 Jan 25;172(3):618-628.e13. doi: 10.1016/j.cell.2017.12.009. Epub 2018 Jan 4. PMID29307492 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29307492/