Peptide Database

Peptide NameBactericidal permeability-increasing protein (BPI)

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibiotic activity

Venom / Toxin ▸ General toxin ▸ Cytotoxin

Standard StatusStandard

Sequence Length187 amino acids

Chemical FormulaC919H1448N252O243S8

DescriptionStandard

        PAALPGAHEPMLLVAITEFVANSAAFTYFTAGALRRNISSNMLPRRFPLQLRTKSMAVFAPQLQELYPDHPMELRLSARRQPLLSCRPDALHGALFGSAEAFVVLPNATCVPAFLLNIDANVTGKPTVAGNRLRGTVKLAGGAELPPGWAQGLPVPQVKKLENLLKFGLWLFGVPWANSECCPHAVP
    

Molecular Weight20171.39 Da

Isoelectric Point (pI)9.51

Net Charge (pH 7.0)6.29

Net Charge (pH 7.4) 5.94

Charge Density (pH 7.0) 0.0336

GRAVY Index0.16

Hydrophobic Moment 0.60

Boman Index0.15

Instability Index55.18

Aliphatic Index 96.10

Aromaticity 0.0802

Extinction Coeff. Reduced 19480.00

Extinction Coeff. Oxidized 19730.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 7714.82

LogP -85.03

H-bond Donors 263.0

H-bond Acceptors 261.0

Rotatable Bonds 631.0

Heavy Atoms 1422.0

Ring Count 42.0

Amide Bonds 201.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0325584 VERIFIED: NO

Provenance & Taxonomy

OrganismBucorvus abyssinicus (Northern ground-hornbill) [Animal]

FamilyBPI

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Anti-Gram-negative Cytotoxin

TargetGram-negative bacteria