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MYP_161737
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Basic Information
Um5
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antiviral
Antiviral ▸ Anti-Hepatitis virus ▸ Anti-HCV
Antiviral ▸ Virucidal activity
Enzyme modulation ▸ Enzyme inhibition ▸ Infection inhibition
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Standard
13 amino acids
C76H116N16O16
Standard
Sequence
IFKAIWSGIKSLF
Physicochemical Analysis
1509.83 Da
10.00
1.76
1.55
0.1352
1.08
0.63
0.47
-15.39
127.69
0.2308
5500.00
5500.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
520.81
-0.50
19.0
18.0
49.0
108.0
4.0
12.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0269818 VERIFIED: YES
Provenance & Taxonomy
Urodacus manicatus [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial
Escherichia coli
15 μM
MIC
PMID28067810 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/28067810/
RECORD: Rec_0303910 VERIFIED: YES
Provenance & Taxonomy
Heterometrus petersii [Animal]
Structure & Mods
topology not specified [Not included yet]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Antiviral
PaperPubMed PMID: 20950663 PMID20950663 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/20950663/
RECORD: Rec_0312548 VERIFIED: YES
Provenance & Taxonomy
Heterometrus petersii [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antiviral
L. fleischmannii, Listeria monocytogenes
2 μM
MIC
PaperA new natural alpha-helical peptide from the venom of the scorpion Heterometrus petersii kills HCV
RECORD: Rec_0331912 VERIFIED: YES
Provenance & Taxonomy
Heterometrus petersii [Animal]
754296
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Antiviral Anti-HCV Infection inhibition
Hepatitis C virus (HCV) | Huh7.5.1 cells
5 μM
IC50
Mammalian: 20 h; Yeast: 30 min; E. coli: >10 h
PaperA new natural α-helical peptide from the venom of the scorpion Heterometrus petersii kills HCV. | Yan R, Zhao Z, He Y, Wu L, Cai D, Hong W, Wu Y, Cao Z, Zheng C, Li W. | Peptides. 2011 Jan;32(1):11-9. | DOI:10.1016/j.peptides.2010.10.008 | PMID:20950663 PMID20950663 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/20950663/
RECORD: Rec_0372082 VERIFIED: YES
Provenance & Taxonomy
Insecta [Animal]; Arthropoda [Animal]
50557; 6656
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial
PMID22342498 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22342498/
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