Peptide Database

Peptide NameUnnamed

Function Ontology

Antimicrobial

Antiviral

Antiviral ▸ Anti-HIV

Antiviral ▸ Anti-Pneumovirus ▸ Anti-RSV

Antiviral ▸ Antiviral mechanism ▸ Viral entry inhibition ▸ Entry inhibitor

Antiviral ▸ Antiviral mechanism ▸ Viral fusion inhibition ▸ Fusion inhibitor

Standard StatusStandard

Sequence Length35 amino acids

Chemical FormulaC187H285N45O62S

DescriptionStandard

        DFLEENITALLEEAQIQQEKNMYELQKLNSWDVFG
    

Molecular Weight4187.59 Da

Isoelectric Point (pI)4.05

Net Charge (pH 7.0)-6.22

Net Charge (pH 7.4) -6.44

Charge Density (pH 7.0) -0.1778

GRAVY Index-0.60

Hydrophobic Moment 0.41

Boman Index-0.01

Instability Index61.25

Aliphatic Index 92.00

Aromaticity 0.1143

Extinction Coeff. Reduced 6990.00

Extinction Coeff. Oxidized 6990.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 1781.27

LogP -14.10

H-bond Donors 57.0

H-bond Acceptors 57.0

Rotatable Bonds 145.0

Heavy Atoms 295.0

Ring Count 5.0

Amide Bonds 41.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0235342 VERIFIED: YES

Provenance & Taxonomy

OrganismSimian immunodeficiency virus [Virus]

FamilyVirus-derived peptide

Tax ID11723;0

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antiviral Entry inhibitor Fusion inhibitor

TargetSimian immunodeficiency virus (gp160)

MethodCell-fusion assay

PaperFusion proteins comprising DP-178 and other viral fusion inhibitor peptides useful for treating aids | Dani Paul Bolognesi, Thomas James Matthews, Carl T. Wild, Durham, Shawn O'Lin Barney, Dennis Michael Lambert, Stephen Robert Petteway, Alphonse J. Langlois | Duke University, Durham, NC (US) | Patent:US7122190 Evidence URLhttps://patents.google.com/patent/US7122190/en PatentUS7122190

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